Delab

Societe De Conseils De Recherches Et D'applications Scientifiques (s.c.r.a.s.)

Societe De Conseils De Recherches Et D'applications Scientifiques

Societe De Conseils De Recherches Et D'applications Scientifiques Sas

Roland Cherif Cheikh

Christophe Aubert

A method for implanting or inserting a solid or semisolid formulation containing at least one active principle uses a device comprising one part set inside the body of the patient and which conditions the solid or semisolid form, brings these conditioning action to the deposit site, injects or inserts in this deposit site, and withdraws after injection or insertion, with one part remaining outside and activating the functions of the device. The invention also concerns a sustained-release solid formulation for parenteral administration comprising a homogeneous mixture of an active principle in non-dispersed state and of a biologically compatible and biodegradable excipient, in which the amount of active principle is at least 50% by weight.

Device for local administration of solid or semi-solid formulations and delayed-release formulations for proposal parenteral administration and preparation process

A syringe for parenteral injection of a semi-solid formulation. The syringe includes a hollow element forming a reservoir for the semi-solid product to be injected between a plunger and a needle hub urged in contact with the reservoir end. The plunger comes into direct contact with the hub when the dose contained in the reservoir-forming element has been injected. The element forming a reservoir and the needle are maintained mutually interlocked at the hub through a mount or case receiving the element forming a reservoir.

Syringes for administering pasty or semi-solid formulations

An injection device for intramuscular or subcutaneous injection of solid or semi-solid medicaments is disclosed. The device includes main body member having a needle attached thereto. A protective sleeve covers the needle and retracts into the main body member when the device is pressed against the skin of a patient. A plunger with an attached rod maintains the medicament in the patient as the needle is withdrawn.

Safety injection device

A method comprising the following steps: preparing in a vacuum a dry form ( ) of an active principle, as well as a liquid ( ), and drawing this liquid into the dry form, by the action of the vacuum to obtain an injectable preparation. The device comprises a gastight syringe ( ) to condition under vacuum the dry form, a reservoir ( ) containing the liquid ( ) and a cap ( ) forming a connector between the syringe and the liquid reservoir, the injection needle ( ) of the syringe being driven into the septum ( ) of the cap ( ). The invention enables a preparation which is directly injectable by an automatic rehydration step to be obtained; indeed, after activation, the extemporaneous preparation is automatic since the device elements move by themselves under the action of the liquid which is drawn by suction into the volume under vacuum containing the solid formulation ( ).

Method for preparing an injectable preparation and device for implementing same

The invention features an implantable device for the automatic delivery of an active ingredient according to an adjustable delivery profile. The device includes a housing; a reservoir operatively connected to the housing and arranged to store a solid composition including the active ingredient; an actuator arranged within the housing to move the solid composition from the reservoir to a transit area, wherein the solid composition exits the housing at the transit area; a controller that acts on the actuator to adjust movement of the solid composition out of the housing according to the adjustable delivery profile; and a power source arranged to provide energy to the actuator and the controller. The solid composition can be an elongate, solid composition comprising a drug, and up to 90% of a carrier, wherein the composition has a cross-section of less than 0.5 mm, and wherein the drug and the carrier are selected and compounded in a proportion such that the drug is immediately released from the carrier upon contact with a liquid.

Methods and apparatus for the delivery of solid drug compositions

Method and apparatus for the delivery of elongate solid drug compositions

Needle-less parenteral introduction device

The invention features an implantable device for the automatic delivery of an active ingredient according to an adjustable delivery profile. The device includes a housing; a reservoir operatively connected to the housing and arranged to store an elongate solid composition including the active ingredient, such as a filament of tape; an actuator arranged within the housing to move the solid composition from the reservoir to a transit assembly, providing a water-tight seal wherein the solid composition exits the housing at the transit assembly; a controller that acts on the actuator to adjust movement of the solid composition out of the housing according to the adjustable delivery profile; and a power source arranged to provide energy to the actuator and the controller. The solid composition can be an elongate, solid composition comprising a drug, and up to 90% of a carrier, wherein the composition has a cross-section of less than 0.5 mm, and wherein the drug and the carrier are selected and compounded in a proportion such that the drug is immediately released from the carrier upon contact with a liquid.

Apparatus for the delivery of elongate solid drug compositions

A needle-less device for the parenteral administration of a medicament is disclosed. The medicament has the shape of one end of a toothpick. It is placed in the bore of a barrel with the barrel having the shape of a nosecone at one end. A plunger is inserted into the other end of the bore. The plunger forces the medicament through the skin and into the subcutaneous layer of the patient without the need for penetration of the skin by a needle.

An osmotic pump comprises a housing (2) within which is a delivery chamber (5) separated from an osmotic salt chamber (7) by impermeable moveable pressure responsive means such as a piston (6) or a flexible membrane. The osmotic salt chamber (7) is separated from a source of osmotic fluid, e.g. an osmotic fluid chamber (12), by a semipermeable membrane (96,36), optionally mounted in a piston (9,23). A fluid barrier isolates the osmotic salt chamber (7) from the source of osmotic fluid for storage of the pump, and may be inactivated when the pump is to be used. The fluid barrier may be a foil sheet (10), inactivatable by rupture, or a piston and a fluid bypass arrangement (21,23). Activation of the osmotic pump may be effected in some embodiments by loading the discharge chamber (5) with the agent to be delivered and in other embodiments by movement of a plunger (16), under manual control or, if the plunger is pre-biassed, by release of a locking means (18) which holds it in position.

Growing community of inventors

Issy les Moulineaux, France

Roland Cherif Cheikh