Schwarz Pharma Limited

Roisin Browne

Michael Kilkelly

The present disclosure relates to a process for the preparation of 2-(3 -diisopropylamino-1-phenylpropyl)-4-(hydroxymethyl)phenol or its phenolic monoesters or salts thereof, characterized by the steps of a) reacting a compound of formula (II) with a mixture of a Grignard initiator and Mg in a solvent; b) optionally reducing the temperature of the Grignard reagent to a lower temperature than in step a), and reacting the resulting Grignard reagent with an excess of a carbonate in a solvent, to obtain a compound of formula (III) wherein A is a C-Calkyl, and the further reacting the compound of formula (III) in a known manner to obtain the desired end product. 

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Co. Tipperary, Ireland

Roisin Browne