Orca Pharmaceuticals Limited

Roine Inge Olsson

Clive McCarthy

Naomi Went

The present invention provides compounds of formula (I), wherein A, A, Z, Z, Z, R, R, R, R, R, R, n, p and q are as defined herein. In certain embodiments, the compounds of the invention are ROR&#x3b3;t antagonists. In other embodiments, the compounds of the invention are useful in the treatment and/or prevention of inflammatory and autoimmune conditions. 

Indazole and indole derivatives as inhibitors of retinoic acid related orphan receptor gamma (ROR gamma) for the treatment of immune-related diseases

The invention relates to compounds of formula (I), wherein Rand Rare as defined herein. The compounds of the invention are inhibitors of ROR&#x3b3;t and are useful in the treatment of diseases and conditions mediated by ROR&#x3b3;t. 

Indolyl-containing ROR&#x3b3;t inhibitors

The present invention relates to compounds of formula (I): wherein Rand Rare as defined herein. In certain embodiments, the compounds of the present invention are inhibitors of ROR&#x3b3;t and are useful in the treatment of diseases and conditions mediated by ROR&#x3b3;t.

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Mölndal, Sweden

Roine Inge Olsson