Usv Pharmaceutical Corporation

Rorer Pharmaceutical Corporation

Rohit M Desai

James R Shroff

Raymond Youssefyeh

Ernest Magnien

Utpal Chakraborty

Bernard Loev

Raymond D Youssefyeh

Thomas D Lee

Edward S Neiss

Quinolinyl ether or thioether tetrazoles as agents for the treatment of

Aryl and Heteroaryl Ethers are used for their anti-inflammatory and anti-allergic properties.

Aryl and heteroaryl ethers as agents for the treatment of hypersensitive

This invention relates to novel lipoxygenase inhibitors possessing anti-inflammatory and anti-allergic activities. The present new compounds are di- and tetra-hydroquinoline or di- and tetra-hydronapthalene derivatives, more particularly, 1,2-, 1,4-, 5,6-, or 7,8-dihydro; 1,2,3,4-tetrahydro-; 5,8-dihydro-; or 5,6,7,8-tetrahydroquinoline or napthalene derivatives of a compound of the formula: ##STR1## and oxides, quaternary ammonium salts and acid salts thereof; wherein A is CH or N;

1,2-Dihydro; 1,2,3,4-tetrahydro; 5,8 dihydro; and

Unsaturated heterocyclic dihydropyridines of the formula: ##STR1## wherein the substituents defined herein have been found to have useful antihypertensive activity.

Antihypertensive 4[(3-alkylamino-2-hydroxypropyl)-oxyiminomethyl

Compounds of the formula ##STR1## wherein R is hydrogen, alkyl, alkoxy, halo, amino, alkylamino, dialkylamino, hydroxy, nitro, trifluoromethyl, mercapto, or alkylmercapto, and may be the same or different,

N-(-2-Pyrimidinyl)-4-aryl-4-[N'-(alkylamino alkyl)]-piperidinamide

Compounds of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are independently hydrogen, lower alkyl, phenyl or phenyl-lower alkyl,

Pyridylacyl-hydroxamates

Compounds of the formula ##STR1## wherein R is lower alkyl, phenyl, lower alkenyl, cycloalkyl and substituted phenyl;

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Millwood, NY, United States of America

Rohit M Desai