Miroculus Inc.

Rohit Lal

Mais Jehan Jebrail

Foteini Christodoulou

Eduardo Cervantes

Ana Eugenia Carvajal

Mark Lewis

Jorge Abraham Soto-Moreno

Ik Pyo Hong

Nikolay Sergeev

Mathieu Gabriel-Emmanuel Chauleau

Poornasree Kumar

Juan Matias DeCarli

Spencer Seiler

Gregory Ray

Yu-Hung Chen

Paul Mathew Lundquist

Alejandro Tocigl

Jobelo Andres Quintero Rodriguez

John Peter Cannistraro

Rodolfo Wilhelmy-Preciado

Gareth Scott

Jair Giovanny Beltran-Vera

Eugenia Carvajal

Methods and apparatuses for sequencing by synthesis using mechanical compression. These methods and apparatuses may mechanically control microfluidic movement using a force applicator and an elastically deformable sheet.

Sequencing by synthesis using mechanical compression

Methods and apparatuses for mechanically controlling microfluidic movement using a force applicator and an elastically deformable sheet are described herein. These apparatuses may include a mechanical microfluidics actuator devices and a cartridge. A microfluidic droplet may be moved or displaced within an air gap of the cartridge by applying a compressive force locally and selectively reduce the gap width of the air gap near the microfluidic droplet causing the microfluidic droplet to move toward the reduced gap. Compressive forces may also be used to divide, join, mix or perform other operations on the microfluidic droplets.

Methods of mechanical microfluidic manipulation

Digital microfluidic (DMF) methods and apparatuses (including devices, systems, cartridges, DMF readers, etc.), and in particular DMF apparatuses and methods adapted for large volume. For example, described herein are methods and apparatuses for DMF using an air gap having a width of the gap that may be between 0.3 mm and 3 mm. Also described herein are DMF readers for use with a DMF cartridges, including those adapted for use with large air gap/large volume, although smaller volumes may be used as well.

Digital microfluidics devices and methods of using them

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San Francisco, CA, United States of America

Rohit Lal