Council of Scientific and Industrial Research

Other

Kulkarni, Amol, Arvind

Joshi, Rohini, Ramesh

Joshi, Ramesh, Anna

Rohini Ramesh Joshi

Ramesh Anna Joshi

Uttam Ramrao Kalkote

Mukund Keshav Gurjar

Digambar Vitthal Gokhale

Thottapillil Ravindranathan

Sanjay Narayan Nene

Vithal Venkatrao Jogdand

Kulbhushan Balwant Bastawde

Bhaskar Ganapatrao Gaikwad

Shamrao Ganapatrao Patil

Amol Arvind Kulkarni

Asmita Ashutosh Prabhune

Ravindranathan Thottapillil

Sandeep Raghunath Ghorpade

Ravindranathan Thottappillil

Kulbhussan Balwant Bastawade

Nilesh B Karade

M K Gurjar

Nayana Tushar Nivangune

Digamber Vitthal Gokhale

Kulbhushan Balwant Bastawade

Sandhya Suresh Sudge

Manisha Abdhiman Jagtap

Disclosed herein is a continuous tubular reactor based conversion of acetophenones to amino substituted acetophenones wherein the nitration is carried out at &#x2212;10 to 10&#xb0; C. followed by reduction to m-nitrophenone resulting in uniform output of product, said process comprising the steps of: a) Nitrating acetophenone with nitrating agent (nitration mixture or fuming nitric acid) at &#x2212;10 to 10&#xb0; C.; b) Isolating m-nitro acetophenone from a mixture of o and m-nitro acetophenone and c) Reducing the m-nitro to obtain m-amino acetophenone.

Continuous two step flow synthesis of M-amino acetophenone

The present invention relates to a process for the preparation of [S(&#x2212;) amlodipine-L(+)-hemi taratarte] from RS amlodipine base using L(+) tartaric acid in the presence of dimethyl sulfoxide.

Process for the preparation of S(&#x2212;) amlodipine-L(+)-hemi taratarte

A process for the preparation of pharmaceutically acceptable salts of chiral Amlodipine namely S(&#x2212;) Amlodipine and R(+) Amlodipine from without isolation of a free base from with optical purity rank between 96-99% is described in the present invention. The process comprises resolving RS amlodipine base using of L(+) or D(&#x2212;) tartaric acid to obtain salt of corresponding to the acid used in ee rang from 96-99%.

Process for preparation of chiral amlodipine salts

The present invention provides a process for preparation of optically active azabicyclo heptanone derivates using lactamases that will react with racemic lactam of formula (I) to give a single enanotiomer of lactam (III) and the corresponding ring opened compound of formula (IV) in an enantiomerically pure form.

Process for the preparation of optically active azabicyclo heptanone derivatives

A process for the preparation of S(&minus;) Amlodipine salts which comprises reaction of S(&minus;)Amlodipine base with a solution of pharmaceutically acceptable acid such as benzene sulfonic acid, oxalic acid, maleic acid, succinic acid and p-toluene sulfonic acid. The reaction is carried out in the presence of an organic solvent at room temperature. The organic solvents include alcohols like ethanol methanol 2 propanol hydrocarbons like toluene and polar solvent like dimethyl sulfoxide. The salt is obtained by addition of water and isolation of the salt formed by filtration. The unique feature of the invention is production of S(&minus;) Amlodipine besylate in good chemical yield, high enantiomeric purity and with the quality required for preparation of pharmaceutical composition i.e. tablet formulation.

Process for making S(-) Amlodipine salts

The present invention provides a method to prepare alkyl-4-&lsqb;2(phthalimido)-ethoxy&rsqb;-acetoacetate which are useful in the manufacture of anti-hypertensive and anti-ischaemic drugs by reacting 2(phthalimido)-ethoxyacetic acid with thionyl chloride and then reacting the acid chloride product obtained with Meldrums acid.

Process for the preparation of alkyl 4&lsqb;2-(phthalimido)ethoxy&rsqb;-acetoacetate

Process for the preparation of 4(R)-hydroxy cyclopent-2-en1(S)-acetate

A microbial process for the preparation of D(-)-N-carbamoylphenylglycine from DL-5-phenylhydantoin which comprises culturing the strain pseudomonas sp. having Accession No. NCIM 5070 (ATCC 55940) and deposited in National Collection of Industrial Microorganisms (NCIM), National Chemical Laboratory (NCL) (India), having hydantoinase activity, in a medium for 16-20 hours, separating the cells by centrifugation, treating the solid cells obtained with DL-5-phenylhydantoin in buffer, at a temperature in the range of about 25-30&deg; C. for a period of about 2-6 hours, acidifying the mixture to obtain solid D(-)-N-carbamoylphenylglycine, and separating the product by filtration.

Microbial process for the production of D(-)-N-carbamoylphenylglycine

The present invention relates to a process for the preparation of D(-)N-carbamoylphenylglycine, by growing Pseudomonas sp deposited at National Collection of Industrial Microorganisms, Pune, India and at American Type Cultural Centre, Rockville, U.S.A and afforded accession No. ATCC 55940 in a conventional nutrient, medium, suspending the cells in alkaline buffer containing buffer, acidifying the broth to obtain the product.

Halophilic Pseudomonas strain having accession No.NCIM 5109 (ATCC 55940)

A microbial process for the preparation of D(-)-N-carbamoylphenylglycine from DL-5-phenylhydantoin which comprises culturing the strain pseudomonas sp. having Accession No. NCIM 5070 (ATCC 55940) and deposited in National Collection of Industrial microorganisms (NCIM), National Chemical laboratory (NCL) (India), having hydantoinase activity, in a medium for 16-20 hours, separating the cells by centrifugation, treating the solid cells obtained with DL-5-phenylhydantoin in buffer, at a temperature in the range of about 25-30.degree. C. for a period of about 2-6 hours, acidifying the mixture to obtain solid D(-)-N-carbamoylphenylglycine, and separating the product by filtration.

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Maharashtra, India

Rohini Ramesh Joshi