Novartis Ag

Other

Rohan Eric John Beckwith

Ritesh Bhanudasji Tichkule

Simone Bonazzi

Thomas Zabawa

Artiom Cernijenko

Gabriel Grant Gamber

Chandra Vargeese

Michael Scott Visser

Jeremy Lee Baryza

Cameron Chuck-munn Lee

Tanzina Fazal

Junping Zhao

Laura Ellen West

Shuangxi Wang

Crystal Byers

Andrew John Geall

Fupeng Ma

Luis Brito

Nathaniel F Ware

Brian Addison DeChristopher

James Bradner

Noel Marie-France Thomsen

Aleem Fazal

Andrei Alexandrovich Golosov

Philip Lam

Jonathan M Solomon

Carla Patricia Pinto Guimaraes

Marc Horst Peter Hild

Seth Carbonneau

Gregory Motz

Nathan Thomas Ross

Carleton Proctor Goold

Cameron Chuck-Munn Lee

The invention provides compositions including a fusion polypeptide and methods for making a fusion polypeptide that includes a COF1/CRBN-binding polypeptide, COF2/CRBN-binding polypeptide, or COF3/CRBN-binding polypeptide and a heterologous polypeptide of interest.

Compositions and methods for selective protein degradation

The present disclosure provides a compound of Formula (I'):

3-(5-amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof

The present disclosure provides a compound of Formula (I'): 

3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof

This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R, R, Rand Rare defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.

Lipids and lipid compositions for the delivery of active agents

This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.

This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R-R, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.

This invention provides for a compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein R, R, Rand Rare defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues. 

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Maynard, MA, United States of America

Rohan Eric John Beckwith