Cedars-sinai Medical Center

Rohan Dharmakumar

Ivan Cokic

Debiao Li

Sotirios A Tsaftaris

Hsin-Jung Yang

The invention provides various methods for imaging a subject's cardiovascular system. The imaging methods may be used to diagnose or prognose various cardiovascular diseases in the subject, without contrast agents or radioactive tracers.

Highly-timed resolved myocardial blood-oxygen-level-dependent magnetic resonance imaging

There are provided methods for diagnosing coronary heart disease in a subject in need thereof comprising administering an admixture comprising COto a subject to reach a predetermined PaCOin the subject to induce hyperemia, monitoring vascular reactivity in the subject and diagnosing the presence or absence of coronary heart disease in the subject, wherein decreased vascular reactivity in the subject compared to a control subject is indicative of coronary heart disease. There are also provided methods for increasing sensitivity and specificity of BOLD MRI.

Assessment of coronary heart disease with carbon dioxide

The invention is directed to methods for diagnosing reperfusion/non-reperfusion hemorrhage and predicting cardiac arrhythmias and sudden cardiac death in subjects comprising using imaging techniques to detect regional iron oxide deposition. The invention also provides treatment methods for subject at increased risk of sudden cardiac death.

Assessment of iron deposition post myocardial infarction as a marker of myocardial hemorrhage

The invention provides various methods of identifying myocardial infarction (MI) patients who have microvascular obstruction (MO), persistent microvascular obstruction (PMO), reperfusion hemorrhage, iron deposition, chronic iron deposition, and/or fat infiltration/accumulation. The invention provides various methods of identifying myocardial infarction (MI) patients who are at risk of prolonged inflammation burden in heart, adverse cardiac remodeling, electrical abnormality, mechanical abnormality, malignant cardiac arrhythmia, ischemic heart failure, and/or sudden cardiac death. The invention also provides various methods of treating these MI patients with chelation drugs, anti-inflammatory drugs, fat-lowering drugs, cooling therapies, or device therapies, or their combinations.

The invention provides various methods for imaging a subject's cardiovascular system. The imaging method may be used to provide a diagnosis or prognosis of various cardiovascular diseases in the subject, without contrast agents or radioactive tracers, and further generating a Gaussian Mixture Model to obtain a reference value of a normal myocardium.

Robust myocardial blood oxygen level dependent magnetic resonance imaging with long acting coronary vasodilators

The invention provides methods for diagnosing coronary heart disease in a subject in need thereof comprising administering an admixture comprising CO2 to a subject to reach a predetermined PaCO2 in the subject to induce hyperemia, monitoring vascular reactivity in the subject and diagnosing the presence or absence of coronary heart disease in the subject, wherein decreased vascular reactivity in the subject compared to a control subject is indicative of coronary heart disease. The invention also provides methods for increasing sensitivity and specificity of BOLD MRI.

Provided herein are methods for reducing ischemia-reperfusion injury and/or microvascular obstructions by administering to the subject effective amounts of carbon dioxide and oxygen before, during and/or after re-establishing perfusion. In some embodiments, the methods further include using therapeutic hypothermia.

Growing community of inventors

Moorpark, CA, United States of America

Rohan Dharmakumar