Vectura Delivery Devices Limited

Pixeloptics, Inc.

Vectura Gmbh

National Semiconductor Corporation

Merck Patent Gmbh

Mitsui Chemicals, Inc.

Boehringer Ingelheim International Gmbh

Merck Patent Gesellschaft MIT Beschrankter Haftung

Hpo Assets LLC

Lipha Sa

Roger William Clarke

Stephen William Eason

Andreas Mark Meliniotis

Joshua N Haddock

William Kokonaski

Quentin John Harmer

Matthew Paul Wright

Matthew Neil Sarkar

Liam Philip McGuinness

Ronald D Blum

Peter Alan Evans

Darryl Cotton

Ivan Milivojevic

John Deamer

Liam Mcguinness

Luu Thanh Nguyen

Peter Deane

Ken Pham

William Paul Mazotti

Venkatramani S Iyer

Bruce Carlton Roberts

Peter Brian Wilson

David Gregory Ahern

John P Briant

Michael R Nelson

Janet E Townsend

Michael Edgar Newton

Mike Paul Sheldon

Christopher James Smith

Jia Liu

Yongseon Koh

Mark Mattison-Shupnick

James Daniel John

Philip John Rawlins

Clive P Catterall

Peter Crossley

Emma Lesley Williamson

Oliver Taylor Harvey

Dominic Charles Reber

Seth Thomas

Philip Smith

Hau Thanh Nguyen

Jens Besseler

Simon James Smith

Ralf Thoemmes

Tobias Kolb

Jessica Frentzel-Beyme

Raymond Anthony Edgson

Graham Roger Gibbins

Simon Burge

Allan Carmichael

David Robinson

Michael Sheldon

Paul Goodwin

Liam Philip McGuiness

Andrew Solly

Emily Pettitt

Matt Garwood

Mitul Lad

Philip John Swanbury

Birgit Donker

Donna Joy Wilson

Mark-Mattison Shupnick

Emma Williamson

Andreas Meliniotis

A dry powder inhaler is provided. The inhaler is adapted for detachably mounting a compliance monitor having a pressure sensor. The inhaler has a housing comprising first and second shell parts, and a mouthpiece which defines an inhalation passage. An external surface of the housing has an orifice. A conduit from the orifice to the inhalation passage is formed by a channel in one of the shell parts and a corresponding channel cover in the other shell part. When the compliance monitor is mounted on the housing, the pressure sensor is adjacent to the orifice and is in fluid communication with the inhalation passage via the conduit.

Inhaler for use with a compliance monitor

The present invention provides an inhaler comprising a housing which contains a blister strip having a plurality of blisters which contain powdered medicament for inhalation; a mouthpiece through which the medicament is inhaled by a user; an indexing wheel for indexing the blister strip; an opening mechanism for opening the blisters; an actuator which is movable between a first position and a second position in order to operate the indexing wheel and the opening mechanism; and a coupling mechanism for coupling the actuator to the indexing wheel so that the indexing wheel rotates together with the actuator during part of the motion of the actuator; characterized in that the coupling mechanism comprises a shuttle that rotates on the same axis as, and translates axially relative to, the indexing wheel.

Dry powder inhaler

The present invention provides an inhaler comprising a housing which contains a blister strip having a plurality of blisters which contain powdered medicament for inhalation, a mouthpiece mounted to the housing through which the medicament is inhaled by a user, an indexing and opening mechanism for indexing the blister strip and for opening the blisters which is operated by an actuator, wherein the blister strip is indexed by forward motion of the actuator from a first position to a second position, such as by opening a cover, and is also indexed in the same direction by reverse motion of the actuator from the second positon to the first position, such as by closing the cover.

A process for producing a blister strip is provided. The blister strip contains two or more different formulations of powdered medicament for inhalation. The blister strip has a base in which blister cavities are formed. A first set of cavities each contain a first medicament formulation and are covered by a first lid material. A second set of cavities each contain a second medicament formulation and are covered by a second, separate lid material.

Process for manufacturing a blister strip for a dry powder inhaler

An inhaler is provided, comprising a housing which contains a blister strip having a plurality of blisters which contain powdered medicament for inhalation; a mouthpiece mounted on the housing through which the medicament is inhaled by a user; an actuator; a blister piercing member; an indexing wheel for sequentially moving each blister into alignment with the blister piercing member when the user operates the actuator; an actuator gear, mounted for rotation about a first axis, which is driven by the actuator and which comprises an actuator gear element; and a drive gear for driving the indexing wheel, mounted for rotation about a second axis, which engages with the actuator gear element. The inhaler is characterized in that the gear ratio between the actuator gear element and the drive gear varies as they rotate during operation of the actuator.

Inhaler

The invention provides a dosing system for an inhalation device, comprising a filling chamber (); a reservoir chamber () which supplies liquid () to an aerosol generator (); and a plunger () which includes an overflow chamber () and which is pivotable about a hinge (). The filling chamber has an inner wall () which is higher on the side adjacent to the hinge than on the opposite side. When the filling chamber is filled with liquid and the plunger is pivoted into the filling chamber, part of the liquid is displaced over the lower side () of the inner wall into the reservoir chamber and some or all of the remaining liquid is displaced into the overflow chamber. The invention also provides an inhalation device comprising the dosing system and a method for dosing liquid to the inhalation device.

Dosing system for a nebulizer

A dry powder inhaler with a blister folding device can include a housing to receive a single blister containing a dose of medicament for inhalation by a user, and a mouthpiece through which a dose of medicament is inhaled by a user and a blister opening device. The blister opening device can include a blister support element for supporting a blister containing a dose of medicament for inhalation by a user, and a blister folding element co-operable with the blister support element. The blister folding element and the blister support element can be movable relative to each other between a first position, for insertion of the blister into or onto the blister support element, and a second, burst, position in which the blister folding element has co-operated with the blister support element.

Combined inhaler and monitor

Monitor for an inhaler

A multi-dose dry powder inhaler with a blister folding device is provided. The inhaler comprises a housing containing a blister strip, and a blister opening device. The blister strip comprises a plurality of individual blisters, each blister containing a dose of medicament for inhalation by a user. The blister opening device comprising a blister support element for supporting one of said blisters, and a blister folding element co-operable with the blister support element, the blister folding element and the blister support element being movable relative to each other between a first position, permitting movement of said blister into or onto the blister support element, and a second, burst, position in which the blister folding element has co-operated with the blister support element. Movement from the first position to the second position causes two spaced apart portions of said blister to each fold relative to the remainder of the blister to produce two spaced apart openings, each opening extending along the circumference of the blister bowl, beginning and terminating at points located on the fold line No piercing of the blister at any stage is required.

Dry powder inhaler with blister bursting device

Nebulization device

An inhaler comprising a housing defining a chamber to receive a strip having a plurality of blisters each containing a dose of medicament for inhalation by a user is disclosed. It comprises an actuating lever and a blister strip drive member rotatably mounted in the chamber to sequentially move each blister into a blister opening position. The blister strip drive member and the actuating lever comprise a drive gear and a drive gear element, respectively, that cooperate to effect rotation of the blister strip drive member in response to rotation of the actuating lever. The drive gear and drive gear element are disposed on the outside of the housing remote from the chamber.

An inhaler comprising a housing defining a chamber to receive a strip having a plurality of blisters each containing a dose of medicament for inhalation by a user is disclosed. It comprises an inhaler comprising a housing to receive a strip having a plurality of blisters, each blister having a puncturable lid and containing a dose of medicament for inhalation by a user, a mouthpiece mounted to the housing and through which a dose of medicament is inhaled by a user, a blister piercing member mounted for rotation about a first axis and an actuating mechanism including an actuating lever mounted for rotation about a second axis to sequentially move each blister into alignment with the blister piercing member, wherein the actuating lever co-operates with the blister piercing member so that the blister piercing member pivots about said first axis in response to rotation of the actuating member from an initial position about the second axis to puncture the lid of an aligned blister so an airflow through the blister is generated to en-train the dose contained therein and carry it, via the mouth-piece, into the users airway when a user inhales through the mouthpiece. The inhaler comprises an actuating lever load control member to control the force that must be applied to the actuating lever to cause it to rotate from its initial position such that a biasing force is applied to the actuating lever throughout all, or at least a substantial portion of, the stroke of the actuating lever.

Growing community of inventors

Cambridge, United Kingdom

Roger William Clarke