Massachusetts Institute of Technology

Harvard College

Genzyme Corporation

Monsanto Technology LLC

Roger Wiegand

Cassandra Celatka

Jon Clardy

Dyann F Wirth

Renato Tony Skerlj

Joseph Cortese

Gregory Hinkle

Ralph Mazitschek

Cecilia M Bastos

Barry S Goldman

Yibin Xiang

Steven C Slater

Mary Lynn Baniecki

Sameer Urgaonkar

Vishal P Patel

Michael L Booker

Elyse M J Bourque

Elyse MJ Bourque

The present invention relates to methods of treating a subject with malaria comprising administering a 2-aminoindole compound represented by Formula: (I)&#x2014;The values and preferred values of the variables in Structural Formula I are defined herein. 

2-aminoindole compounds and methods for the treatment of malaria

Inhibitors of dihydroorotate dehydrogenase (DHODH) for theenzyme have been identified and characterized. The inhibitors have high specificity, submicromolar efficacy against cultured parasite strains, exhibit drug-like properties, and are not overtly cytotoxic.

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The present invention relates to nucleic acid sequences from the bacterium, and, in particular, to genomic DNA sequences. The invention encompasses nucleic acid molecules present in non-coding regions as well as nucleic acid molecules that encode proteins and fragments of proteins. In addition, proteins and fragments of proteins so encoded and antibodies capable of binding the proteins are encompassed by the present invention. The invention also encompasses oligonucleotides including primers, e.g. useful for amplifying nucleic acid molecules, and collections of nucleic acid molecules and oligonucleotides, e.g. in microarrays. The invention also provides constructs and transgenic cells and organisms comprising nucleic acid molecules of the invention. The invention also relates to methods of using the disclosed nucleic acid molecules, oligonucleotides, proteins, fragments of proteins, and antibodies, for example, for gene identification and analysis, and preparation of constructs and transgenic cells and organisms.

Myxococcus xanthus genome sequences and uses thereof

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Wayland, MA, United States of America

Roger Wiegand