Syntex (u.s.a.) Inc.

Roger Whiting

Arthur F Kluge

Arthur M Strosberg

George A Christie

Robin D Clark

Jean-Claude G Pascal

Novel compounds of the general formula ##STR1## and the pharmaceutically acceptable esters and acid addition salts thereof, wherein:

Cardioselective aryloxy- and arylthio- hydroxypropylene-piperazinyl

2-(1,4-Benzodioxan-2-ylalkyl)imidazoles having the general formula ##STR1## wherein R.sup.1 and R.sup.2 are each independently selected from the group consisting of hydrogen, alkyl, optionally substituted phenyl, and optionally substituted phenyl lower alkyl;

2-(1,4-Benzodioxan-2-ylalkyl)imidazoles

2-(1,4-Benzodioxan-2-ylalkyl)imidazoles having the general formula: ##STR1## wherein R.sup.1, and R.sup.2 and R.sup.3 are independently selected from the group consisting of hydrogen, and alkyl, and wherein n is an integer equal to 0, 1 or 2, and the pharmaceutically acceptable acid addition salts thereof, are useful as antidepressants.

2-(1,4-Benzodioxan-2-ylalkyl)imidazoles useful as antidepressants

Compounds of the formula ##STR1## and the pharmaceutically acceptable, non-toxic salts thereof, wherein: R is hydrogen, lower alkyl, or benzyl;

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Roger Whiting