Rutgers, the State University of New Jersey

University of Medicine and Dentistry of New Jersey

Snip Holdings, Incorporated

Roger W Howell

John M Akudugu

Venkata S Neti

Suresh C Srivastava

Radoslav R Adzic

Gilbert R Gonzales

Han Wu

Venkata S V P Neti

Wesley E Bolch

Sreekrishna Murty Goddu

Dandamudi V Rao

Jordan B Pasternack

Behrooz Vaziri

Therapeutic compositions for treating diseased cells such as cancer cells in a patient, formulated from a plurality of therapeutic agents selected from radiopharmaceuticals, chemotherapeutic agents and radionuclide labeled antibodies. Methods for predicting the response of an individual patient's cells to therapeutic intervention are also disclosed.

Method of overcoming therapeutic limitations of non-uniform distribution of radiopharmaceuticals and chemotherapy drugs

Disclosed is a method for predicting the optimal amounts of radiopharmaceutical and/or chemotherapy agents to administer to a patient, by determining the level of saturation of the therapeutic agents in the patient's cells. The method comprises measuring cellular incorporation of the candidate therapeutic agents in a target cell population on a cell-by-cell basis. The method is able to identify an optimal cocktail of therapeutic agents for treatment of a disease. A method of high-throughput drug discovery incorporating this method, and a 2-stage targeting method of treating a disease using this method are also disclosed.

Method of overcoming therapeutic limitations of nonuniform distribution of radiopharmaceuticals and chemotherapy drugs

A system, method and computer program product to determine radiation dose from radionuclides used to treat a patient in need thereof. The present invention allows users to visualize and understand the impact of radionuclide choice, distribution of activity in the cell, distribution of activity among the cells, cell dimensions, cell separation distance, cluster size, and radiobiological response parameters on the capacity to kill populations of cells. All of these parameters can play a substantial role in determining the surviving fraction of cells. Accordingly, this system, method and computer program product can assist in designing treatment plans for therapeutic radiopharmaceuticals suited to individual needs.

Methods and systems for determining the distribution of radiation dose and response

The present invention discloses a method of selectively providing radiation dosimetry to a subject in need of such treatment. The radiation is applied by an implant comprising a body member andSn electroplated at selected locations of the body member, emitting conversion electrons absorbed immediately adjacent selected locations while not affecting surrounding tissue outside of the immediately adjacent area.

Dosimetry implant for treating restenosis and hyperplasia

A variable attenuation apparatus for use with a radiation-blocking liquid and a radiation source having an attenuation chamber capable of containing a layer of the radiation-blocking liquid and an adjustment device for selectively metering the thickness of the layer of the radiation-blocking liquid, whereby changes in the thickness of the layer alter the radiation transmitted through the attenuation chamber. In one embodiment, an adjustment device includes a reservoir for holding the radiation-blocking liquid and a siphon connection device for allowing the transfer of the radiation-blocking liquid between the reservoir and the attenuation chamber, wherein the thickness of the layer in the attenuation chamber varies in response to changes in elevation of said reservoir, so that an increase in the thickness of the layer causes a drop in the radiation transmitted through the attenuation chamber. A substantially linear increase in the thickness of the layer in the attenuation chamber may yield a substantially exponential drop in the radiation dose rate transmitted through the attenuation chamber. A desired dose rate pattern, such as an exponential dose rate pattern, may be delivered by the apparatus. An adjustable irradiator system is presented, and a method for delivering varying temporal radiation dose rates is described.

Method and means for variably attenuating radiation

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Millington, NJ, United States of America

Roger W Howell