Montana State University

Pharmagenesis, Inc.

Roger V Miller

Gary Allan Strobel

David C Sands

Eugene Ford

Concepcion Martinez-Miller

Gregory Kennett

The present invention is directed to a family of unique antimycotic lipopeptide compounds produced by Pseudomonas viridiflava. The lipopeptides are effective against both human and plant fungal pathogens, and are typically characterized by their ability to inhibit growth of Candida albicans. Representative lipopeptides of the invention have molecular weights of 1137, 1153, 1164 and 1181 daltons.

Antifungal compounds from pseudomonas viridiflava

A broad spectrum biological herbicide comprises a mammal-sparing bioherbicide fungal mutant, e.g., a S. sclerotiorum mutant, of limited survival time and geographical dissemination characteristics under standard agricultural conditions. The invention also relates to a method of obtaining herbicides of the invention comprising obtaining viable wild type bioherbicide fungal spores, subjecting these to UV light to reduce the number of viable fungi to less than 5% the initial number of spores, selecting mutants which differ from the wild type in at least one characteristic such as altered phenotype or morphology, and further selecting a mammal-sparing bioherbicide fungal mutant of reduced survival time and geographical dissemination characteristics under agricultural conditions when compared with the wild type. The invention also relates to a method of using the broad spectrum biological herbicide to reduce the number of weeds in an area. The invention also relates to a limited plant spectrum mammal-sparing bioherbicide. The invention further relates to a method for obtaining the bioherbicides according to the invention.

Self-delimiting fungal mutants, bioherbicidal compositions thereof,

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Bozeman, MT, United States of America

Roger V Miller