Beecham Group Plc

Smithkline Beecham Corporation

Beecham Group P.l.c. of Beecham House

Roger T Martin

Francis D King

Michael S Hadley

Ian Thomson Forbes

Graham Elgin Jones

Eric A Watts

Erol A Faruk

Indole derivatives as 5HT.sub.1C antagonists

Indole ureas as 5 ht receptor antagonist

A process is disclosed for the preparation of a compound of formula (I): ##STR1## wherein Ar is aryl or substituted aryl and R.sup.3 is hydrogen, alkyl or aralkyl, which process comprises reducing a compound of formula (II): ##STR2## wherein Ar and R.sup.3 are as defined with respect to formula (I) and R.sup.4 is alkyl. Compounds of formula (I) are useful as chemical intermediates.

Process for preparing aryl-piperidine carbinols and novel intermediates

Compounds of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein: j is 0 or 1;

Azabicyclic intermediates

Compounds of formula (I) and pharmaceutically acceptable salts thereof:

N-('-B-hydroxyethylpiperid-4-yl esters and amides

Azabicyclic benzamide derivatives

Compounds of the formula (I): ##STR1## and pharmaceutically acceptable salts and N-oxides thereof, wherein: R.sub.1 is a C.sub.1-6 alkoxy group;

1-Aza-4-oxa-bicyclo [4,4,0]decane derivatives

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Harlow, United Kingdom

Roger T Martin