University of Texas System

Orthologic Corp.

Roger S Crowther

Darrell H Carney

David J Simmons

William R Redin

Jinping Yang

John S Bergmann

David W Hobson

Andrew Po Kwan Tang

Janet Stiernberg

Andrew Po Tang

Disclosed are pharmaceutical compositions comprising a thrombin peptide derivatives and a chelating agent and/or a pharmaceutically acceptable thiol-containing compound. The pharmaceutical compositions optionally further comprise an antioxidant. Also, disclosed are methods for activating the non-proteolytically activated thrombin receptor in a subject in need of such treatment. The methods comprise the step of administering an effective amount of a thrombin peptide derivative in the pharmaceutical composition described above.

Methods of therapy using pharmaceutical composition for thrombin peptide derivatives

Disclosed is a method of stimulating bone growth at a site in a subject in need of osteoinduction. The method comprises the step of administering a therapeutically effective amount of an agonist of the non-proteolytically activated thrombin receptor to the site.

Stimulation of bone growth with thrombin peptide derivatives

Pharmaceutical composition for thrombin peptide derivatives

Disclosed is a method of stimulating cartilage growth, repair or regeneration at a site in a subject in need of such growth, repair or regeneration. The method comprises the step of administering a therapeutically effective amount of an agonist of the non-proteolytically activated thrombin receptor to the site. Also disclosed is a method of stimulating the proliferation and expansion of chrondrocytes in vitro. The method comprises culturing chrondrocytes in the presence of a stimulating amount of an NPAR agonist.

Stimulation of cartilage growth with agonists of the non-proteolytically activated thrombin receptor

Growing community of inventors

League City, TX, United States of America

Roger S Crowther