Other

Cambridge Enterprise Limited

Vallier, Ludovic

Brons, I. Gabrielle M.

Pedersen, Roger

Roger Pedersen

Ludovic Vallier

Gabrielle Brons

Willem Ouwehand

Sanjay Sinha

Cedric Ghevaert

Christine Cheung

Matthew Trotter

Thomas Moreau

Andreia Bernardo

I Gabrielle M Brons

This invention relates to the forward programming of pluripotent stem cells (PSCs) into megakaryocyte (MK) progenitor cells using the transcription factors GATA1, FLI1 and TAL1. Methods of producing megakaryocyte (MK) progenitor cells and subsequently differentiating them into mature megakaryocytes are provided.

Transcription factor mediated programming towards megakaryocytes

This invention relates to the production of populations of Smooth Muscle Cells (SMCs) of specific embryonic lineages, such as neuroectodermal and mesodermal SMCs. Pluripotent stem cells are cultured in one or more lineage induction media to produce progenitor cells of a defined embryonic lineage, which are then cultured in an SMC induction medium to produce a population of SMCs of the embryonic lineage. Populations of SMCs of defined lineages may be useful, for example, in accurately modelling vascular disease.

Populations of smooth muscle cells of specific embryonic lineages

The invention relates to the isolation and propagation of pluripotent cells isolated from the mammalian late epiblast layer, termed Epiblast Stem Cells (EpiSCs). These cells are useful in a range of applications, including the generation of transgenic animal species.

Pluripotent cells from mammalian late epiblast layer

Pluripotent cells from the mammalian late epiblast layer

This invention relates to the culture of pluripotent cells in a fully humanised chemically defined medium. Cells may be cultured over a prolonged period of time without losing their pluripotent status or may be controllably induced to differentiate into progenitor cells of the three primary germ layers by the addition of differentiation factors, for example differentiation factors which modulate one or more of the Activin/Nodal, FGF, Wnt or BMP signalling pathways.

Differentiation of pluripotent cells into primary germ layer progenitors

This invention relates to the isolation and propagation of pluripotent cells isolated from the mammalian late epiblast layer, termed Epiblast Stem Cells' (EpiSCs). These cells are useful in a range of applications, including the generation of transgenic animal species.

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Cambridge, United Kingdom

Roger Pedersen