Ge Healthcare Limited

Roger Paul Pettitt

Nigel John Osborn

Nigel Anthony Powell

Robert F Chisholm

Alan Peter Clarke

Thanushan Rajanayagam

Brian Higley

The present invention provides an automated method for the preparation ofI-labelled radiopharmaceutical compositions, together with disposable cassettes for use in the method. The use of an automated synthesizer apparatus in the preparation ofI-labelled radiopharmaceuticals is also described. Also described is the use of cassettes of the present invention in the preparation ofI-labelled radiopharmaceuticals.

Automated radiolabelling method

A multi-vial dispensing cassette provides serial dispensement of radiopharmaceutical fluid into a plurality of dispense vials connected in series. Needle holders may be provided for one or more vials in the cassette and at clip may be incorporated into the needle holder. Each dispense vial has a body and a cap with a fill needle and a withdrawal needle. The withdrawal needle of one vial is connected to the fill needle of an adjacent vial.

Multi-vial dispensing

The present invention provides a flow cell that can be used to improve the linear detection range of a radio-detector. The flow cell of the present invention is simple and cost-effective to set up and provides technical advantages over methods known in the prior art, as set out in more detail hereunder. The present invention also provides a method to determine the RCP of a radioactive composition making use of said flow cell, and a HPLC system comprising said flow cell.

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Buckinghamshire, United Kingdom

Roger Paul Pettitt