European Community (ec)

The European Community, Represented by the European Commission

The European Union, Represented by the European Commission

Roger Molinet

Christos Apostolidis

Lothar Koch

Jacques Van Geel

Willem Janssens

Alfred Morgenstern

Hermann Schweickert

Klaus Luetzenkirchen

Bruno Brandalise

Josef M&ouml;llenbeck

Michel Ougier

John McGinley

Methods of using Th-226 or mother radionuclides thereof, namely U-230 or Th-226, in medicine. These radionuclides are particularly appropriate for the treatment of human and/or non-human mammals, in particular for therapeutic, diagnostic (detection/imaging), prophylactic and pain palliation purposes. These radionuclides may be used in various forms for treatment and/or diagnostic purposes, in particular in cationic form or in the form of radioconjugates or bone-targeting complexes. Methods of making such radionuclides.

Radionuclides for medical use

This invention relates to a method and an apparatus for preparing Bi-213 to be integrated in a radioimmunocojugate for human therapeutic use. According to the invention the method comprises the sequence of steps as follows: a) an ampoule containing colloid-free actinium-225, obtained from drying an actinium nitrate solution, is loaded into a container provided with radiation panels ; b) a dissolving medium is poured into the ampoule ; c) the solution obtained in the ampoule is transferred into an ion exchange column ; d) an elution medium is circulated through the column ; e) the eluate containing eluted Bi-213 is pumped towards a vial for quantification and quality control.

Method and apparatus for preparing Bi-213 for human therapeutic use

This invention refers to a method for producing Actinium-225, comprising the steps of preparing a target (,) containing Radium-226, of irradiating this target with protons in a cyclotron and of chemically separating Actinium from the irradiated target material thereafter. According to the invention the proton energy in the cyclotron is adjusted such that the energy incident on the Ra-226 is between 10 and 20 MeV, preferably between 9 14 and 17 MeV. By this means the yield of production of the desired isotope Ac-225 is enhanced with respect to other radioisotopes.

Method for producing Ac-225 by irradiation of Ra-226 with protons

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Linkenheim, Germany

Roger Molinet