National Research Council of Canada

Roger MacKenzie

Jamshid Tanha

Greg Hussack

Christine M Szymanski

Mehdi Arbabi Ghahroudi

Ali Riazi

Mehdi Arbabi-Ghahroudi

is a leading cause of bacterial food-borne diseases in humans, ranging from acute diarrheal disease to neurological disorders. An isolated or purified antibody or fragment thereof specific tois described. The antibody or fragment thereof binds to a flagellar protein and reduces motility of. The antibody or fragment thereof is derived from a heavy chain IgG variable domain fragment (VH) of a camelid animal immunized withflagellar protein. A multivalent form, as well as a phage format, of the antibody or fragment thereof is described. Methods of reducing presence ofin an animal or an animal environment, methods and formulations for treatinginfection, and method of detectingare also described.

Anti-campylobacter jejuni antibodies and uses therefor

The present invention is directed totoxin-specific antibodies, compositions, and uses thereof. The anti-toxin antibodies may be specific for either TcdA or TcdB. The invention also includes methods of treating ainfection, methods of capturingtoxins, and methods of detectingtoxins.

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Ottawa, Canada

Roger MacKenzie