United Therapeutics Corporation

Inregen

Tengion, Inc.

Regenmedtx, LLC

Prokidney

Regenmed, Inc.

Roger M Ilagan

Roger Jeffs

Michael Wade

Thomas Petersen

Manuel J Jayo

Oluwatoyin A Knight

Timothy A Bertram

Sharon C Presnell

Andrew T Bruce

Russell W Kelley

Shay M Wallace

Sumana Choudhury

Eric S Werdin

John W Ludlow

Deepak Jain

Joydeep Basu

Richard Payne

Kelly Guthrie

Namrata D Sangha

H Scott Rapoport

Christopher W Genheimer

Darell McCoy

Craig R Halberstadt

Elias A Rivera

Bryan R Cox

Neil F Robins

Patricia D Tatsumi

Jessica J Reinsch

Benjamin Watts

Thomas Spencer

John Cheadle

Sarah Hogan

Sarah F Quinlan

Carolina Medrano

Maria Pia Rodriguez

Kelly I Guthrie

Russell W Keller

Darrell Mccoy

Scott H Rapoport

Sangha Namtata

I Guthrie; Kelly

Neil Robbins

Sarah A Boyd

Darell Mccoy

Jacob E Shokes

Teresa B Burnette

Dominic M Justewicz

Wendy Sharp

Neil F Robbins

Sangha Namrata

The current application is directed to a method for treating pulmonary arterial hypertension (PAH), comprising: providing isolated endothelial progenitor cells (EPCs); treating the EPCs with prostacyclin, wherein the treated EPCs exhibit a hyperproliferative phenotype with enhanced angiogenic property; and administering a composition comprising the treated EPCs into a subject suffering from PAH.

Treatment of pulmonary arterial hypertension with prostacyclin-treated endothelial progenitor cells

Provided are methods for treating or preventing vasculopathy in a subject in need thereof, comprising administering to the subject a prostacyclin and a mesenchymal stem cell (MSC) or a MSC-conditioned culture medium or administering to the subject a MSC or a MSC-conditioned culture medium that has treated with prostacyclin. Pharmaceutical compositions suitable for such treatments are also provided.

Treatment of vasculopathy with prostacyclin and mesenchymal stem cells

The present invention concerns bioactive renal cell populations, renal cell constructs, and methods of making and using the same.

Bioactive renal cells

The application is directed to a method for treating or preventing vasculopathy comprising administrating to a subject in need thereof a pharmaceutical composition comprising mesenchymal precursor cells (MPCs) and a prostacyclin. Also provided a method for treating or preventing vasculopathy in a subject in need thereof, comprising administering to the subject a prostacyclin and a mesenchymal stem cell (MSC) or a MSC-conditioned culture medium or administering to the subject a MSC or a MSC-conditioned culture medium that has treated with prostacyclin. Pharmaceutical compositions suitable for such treatments are also provided.

Treatment of pulmonary arterial hypertension with mesenchymal stem cells

Provided are methods for treating or preventing vasculopathy comprising administering to a subject in need thereof , ac composition comprising a mesenchymal stem cell (MSC), or a part of a culture medium that has been in contact with the MSC and comprises one or more components of the MSC, or an exosome derived from the MSC. Pharmaceutical compositions suitable for such treatment is also provided.

Enhancement of MSC immunomodulatory properties by treprostinil

The present invention concerns bioactive renal cells populations, renal cell constructs, and methods of making and using the same.

Provided are methods for isolating potent extracellular vesicle or exosome populations from mesenchymal stromal cells, and the use of the isolated extracellular vesicles or exosomes in treating vasculopathy, including pulmonary hypertension, bronchopulmonary dysplasia, and disease and conditions associated with mitochondrial dysfunction.

Extracellular vesicles with enhanced potency

The invention is directed to isolated renal cells, including tubular and erythropoietin (EPO)-producing kidney cell populations, and methods of isolating and culturing the same, as well as methods of treating a subject in need with the cell populations.

Isolated renal cells and uses thereof

Growing community of inventors

Burlington, NC, United States of America

Roger M Ilagan