Biovector Therapeutics, S.a.

Roger Kravtzoff

Didier Betbeder

Ignacio De Miguel

Michel Major

Alain Etienne

Thale Jarvis

Daniel Samain

Li Ding

Pamela Pavco

Pascal E Delrieu

Corinne Segreto

Nadine Candelotto

Igancio De Miguel

Sophie Sixou

Fr&eacute;d&eacute;rique N'guyen

A synthetic particulate vector comprising a non-liquid hydrophilic nucleus which does not have an external lipid layer grafted thereon. A method for preparing a particulate vector by encapsulating an ionizable active principle, vectors obtainable through said method, and pharmaceutical, cosmetological or food compositions containing such vectors are also disclosed.

Synthetic particulate vectors and preparation process

The invention relates to an ionic conjugate, which is stable in a biological medium, and which is comprised of a particle vector with at least one cationic, nonliquid, hydrophilic nucleus and of polyanionic oligonucleotides. The invention further concerns the pharmaceutical compositions containing these conjugates and the use of a particle vector to carry the oligonucleotides to the cells.

Conjugates of a particle vector and oligonucleotides, process for their preparation, and pharmaceutical compositions containing them

A novel method for the mucosal administration of a substance to a mammal is provided. The method comprises contacting a mucosal surface of the mammal with the substance in combination with a Biovector. The Biovector has a core that comprises a natural polymer, or a derivative or a hydrolysate of a natural polymer, or a mixture thereof. A preferred natural polymer is a polysaccharide or an oligosaccharide. The core is optionally coated with an amphiphilic compound, such as a lipid.

Mucosal administration of substances to mammals

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Fourquevaux, France

Roger Kravtzoff