Michigan State University

Stichting Centraal Diergeneeskundig Instituut

Roger K Maes

Johannes Theodorus Van Oirschot

Franciscus Antonius Rijsewijk

Annabel G Wise

Paul M Coussens

John David Reilly

Aivars Vilnis

Matti Kiupel

John M Kruger

Daniel C Taylor

Stephen J Spatz

The present invention relates to the use of novel nucleotide sequences for the M and N region peptide of the ferret coronavirus and derivative products for the diagnosis and treatment of epizootic catarrhal enteritis (ECE) in ferrets.

Compositions for the diagnosis and treatment of epizootic catarrhal enteritis in ferrets

The present invention provides a multiplex RT-PCR/PCR method, which enables in a single assay the simultaneous detection of any combination of bovine rotavirus, bovine coronavirus,, and optionally,strains producing K99 pili or heat-stable enterotoxin STa.

Multiplex RT-PCR/PCR for simultaneous detection of bovine coronavirus, bovine rotavirus, Cryptosporidium parvum, and Escherichia coli

The present invention provides an isolated feline calicivirus and mutants thereof, which were isolated from the urine of a cat with lower urinary tract disorder. The present invention further provides nucleic acid clones of the virus, in particular, a clone which encodes the capsid antigen of the virus. The present invention is useful for providing a live or killed virus vaccine comprising the virus or mutants thereof, a subunit vaccine comprising the capsid antigen of the virus, a nucleic acid vaccine encoding the capsid antigen of the virus, and a recombinant virus vector vaccine encoding the capsid antigen of the virus. The present invention also provides a method for isolating feline calicivirus from urine and an assay for diagnosing cats infected with feline calicivirus.

Feline calicivirus isolated from cat urine and vaccines thereof

A recombinant poxvirus vaccine against feline herpesvirus (FHV-1) is described. The recombinant poxviruses include synthetic genes encoding either a gB or gD precursor polypeptide or mixtures of the two recombinant poxviruses. The vaccine is used to provide immunity to FHV-1 in cats.

Recombinant poxvirus vaccine against feline rhinotracheitis

Method of propagating viruses that replicate in embryonated eggs or in primary cultures of chicken embryo cells on an immortal, virus-free, contact-inhibited, and non-oncogenic chicken embryo cell line. The method supports replication of avian viruses of the Birnaviridae, Coronaviridae, Herpesviridae, Orthomyxoviridae, Paramyxoviridae, Picornaviridae, Polyomaviridae, Poxviridae, and Reoviridae families. The immortal cell line of the present invention supports replication of swine influenza virus, for instance. The cell line is useful for virus isolation diagnostic assays and for propagating virus suitable for live or killed vaccines.

Immortal avian cell line to grow avian and animal viruses to produce

Deletion mutant of bovine herpesvirus type 1 which has a deletion in the glycoprotein gE-gene. The mutant may further have a deletion in the thymidine kinase gene and/or the glycoprotein gI-gene, or have an insertion of a heterologous gene. Recombinant nucleic acid which comprises the gE-gene or a part thereof. Glycoprotein gE, peptides based thereon and complexes of the glycoproteins gE and gI, and antibodies against them. Vaccines and diagnostic kits comprising any one of these materials.

Growing community of inventors

Okemos, MI, United States of America

Roger K Maes