Astrazeneca Ab

Zeneca Limited

Redag Crop Protection Ltd

Other

Roger John Butlin

Thorsten Nowak

Jeremy Nicholas Burrows

Michael Howard Block

Robert Hugh Bradbury

Roger James

Janet Elizabeth Pease

Alan Martin Birch

Christopher John Urch

Stephania Christou

Rebecca Kathryn Booth

Michael James Waring

Alleyn Thomas Plowright

Leonie Campbell

David Stephen Clarke

Paul Michael Murray

William McCoull

Andrew Leach

Philip John Hogan

Petra Johannesson

Ulrik Jurva

Craig Samuel Donald

Suzanne Saxon Bowker

Stuart Norman Lile Bennett

Clive Green

Per Olof Ryberg

Rolf Peter Walker

Graeme Richard Robb

Paul Ro Whittamore

Christer Ralf Westerlund

Peter Gustaf Bonn

Victoria Elizabeth Jackson

Margaret Anne Butlin

Andreas Meudt

Victor Ceban

Robert Darren Morse Davies

Helen Claire Pointon

Mikael Dan Brink

Jonas Rickard Fägerhag

Volker Schnecke

Anette Marie Svensson Henriksson

Jan Magnus Johansson

Annika Ulrika Petersson

Udo Andreas Bauer

Alexander Tobias Noeske

Ragnar Hovland

Jonas Gunnar Barlind

The present invention relates to compounds which are of use in the field of agriculture as fungicides.

Agricultural chemicals

The present invention relates to benzimidazole ethers and related compounds which are of use in the field of agriculture as fungicides.

Benzimidazole compounds as agricultural chemicals

The present invention relates to 2-thiobenzimidazoles of formula (I) which are of use as fungicides. 

Thiobenzoimidazole as fungicides

DGAT-1 inhibitor compounds of formula (I), pharmaceutically-acceptable salts and pro-drugs thereof are described, together with pharmaceutical compositions, processes for making them and their use in treating, for example, obesity 

Substituted pyrazines as DGAT-1 inhibitors

A compound of Formula (I): is useful in the treatment or prevention of a disease or medical condition mediated through glucokinase (GLK or GK), leading to a decreased glucose threshold for insulin secretion.

Therapeutic agents

Compounds of formula (I), or salts thereof, which inhibit acetyl CoA (acetyl coenzyme A):diacylglycerol acyltransferase (DGAT1) activity are provided, wherein R, Rand Rare each independently selected from hydrogen, fluoro, chloro, cyano, trifluoromethyl, trifluoromethoxy and difluoromethoxy; together with processes for their preparation, pharmaceutical compositions containing them and their use as medicaments.

Substituted 5- phenylamino- 1, 3, 4-oxadiazol-2-ylcarbonylamino-4-phenoxy-cyclohexane carboxylic acid as inhibitors of acetyl coenzyme A diacylglycerol acyltransferase

Carbamoyl compounds as DGAT1 inhibitors 190

Compounds of formula (I), and salts and pro-drugs thereof: Formula (I) wherein for example Ris optionally substituted aryl or heteroaryl; Y is a linking group selected from, for example, a direct bond, and a (substituted) alkyl chain; Ris an optionally substituted aryl, an optionally substituted cycloalkyl or an optionally substituted heterocyclic group; are described. Processes to make such compounds and their use as DGAT inhibitors, for example in the treatment of obesity, are also described. 

Oxadiazole derivative as DGAT inhibitors

The invention relates to compounds such as where P is a nitrogen-protecting group, and to processes for preparing these compounds.

Protected forms of N-(3-methoxy-5-methylpiperazin-2-yl)-2-(4-[1,3,4,-oxadiazol-2-yl]phenyl)-pyridine-3-sulphonamide

The use of compounds of formula (I), and salts thereof; and pharmaceutically acceptable in vivo cleavable prodrugs of said compound of formula (I); and pharmaceutically acceptable salts of said compound or said prodrugs; in formula (I), Ring C is phenyl or a carbon linked heteroaryl ring substituted as defined within; Ris an ortho substituent as defined within; n is 1 or 2; A-B is a linking group as defined within; Rand Rare as defined within; Ris hydroxy, hydrogen, halo, amino or methyl; in the manufacture of a medicament for use in the elevation of PDH activity in warm-blooded animals such as humans is described. Pharmaceutical compositions, methods and processes for preparation of compounds of formula (I) are also described

Use of compounds for the elevation of pyruvate dehydrogenase activity

Amides as inhibitors for pyruvate dehydrogenase

A compound of formula (I) wherein: n is 1 or 2; R is chloro, fluoro, bromo, methyl or methoxy; R is as defined within; R is as defined within; and R is hydrogen or fluoro; or a pharmaceutically acceptable salt or an in vivo hydrolysable ester thereof is described. The use of compounds of formula (I) in the production of an elevation of PDH activity in a warm-blooded animal such as a human being are also described. Pharmaceutical compositions, methods and processes for preparation of compounds of formula (I) are detailed.

Substituted N-phenyl 2-hydroxy-2-methyl-3,3,3-trifluoropropanamide derivatives which elevate pyruvate dehydrogenase activity

Compounds of formula (I), pharmaceutically acceptable salts or in vivo hydrolysable esters thereof, wherein: Ring X is phenyl or a six membered heteroaryl ring containing one or two ring nitrogens where said nitrogens are optionally oxidised to form the N-oxide; R and R are substituents as defined within; R and R are defined within and are alkyl or halo alkyl or together form a halocycloalkyl ring; R is a substituent as defined within; Y&mdash;Z is a linking group as defined within; are useful in the production of a elevation of PDH activity in a warm-blooded animal such as a human being. Pharmaceutical compositions, methods and processes for preparation of compounds of formula (I) are described.

Benzenesulfonamide-derivatives and their use as medicaments

A compound of formula (I) wherein: R , R , R , R , R , R and R are as defined within; or a pharmaceutically acceptable salt or an in vivo hydrolysable ester thereof is described. The use of compounds of formula (I) in the production of an elevation of PDH activity in a warm-blooded animal such as a human being are also described. Pharmaceutical compositions, methods and processes for preparation of compounds of formula (I) are detailed.

Chemical compounds

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Macclesfield, United Kingdom

Roger John Butlin