Glaxo Group Limited

Allen Hanburys Limited

Roger Hayes

John W Clitherow

David E Bays

John Bradshaw

Barry J Price

Duncan B Judd

Linda Carey

John W Mackinnon

John W MacKinnon

Michael Martin-Smith

Philip Blatcher

Harry Finch

Eric W Collington

Michael D Dowle

Keith Mills

David F Woodings

Andrew Pearce

William D Ollis

Compounds are described of the formula (1) ##STR1## where: R.sup.1 is a hydrogen atom or a methyl group;

Aminocyclopentyl ethers and their preparation and pharmaceutical

The invention provides compounds of the general formula ##STR1## and physiologically acceptable salts and hydrates thereof, in which one of R.sub.1 and R.sub.2 represents hydrogen, halogen or a C.sub.1-4 alkyl group which may be optionally substituted by hydroxy or C.sub.1-4 alkoxy, and the other represents the group R.sub.4 R.sub.5 NAlk-- in which Alk represents a straight or branched alkylene chain of 1 to 6 carbon atoms;

Heterocyclic derivatives, processes for the use thereof and

The invention provides compounds of the general formula (I) ##STR1## and physiologically acceptable salts, hydrates and bioprecursors thereof, in which the substituents are defined in the detailed description. The compounds show pharmaceutical activity as selective histamine H.sub.2 -antagonists.

Triazole amine compounds, their pharmaceutical compositions and method

This invention relates to compounds of the general formula (I) ##STR1## and physiologically acceptable salts and hydrates thereof, in which R.sub.1 represents a hydrogen atom or an alkyl, alkanoyl, aroyl or trifluoroalkyl group;

Heterocyclic derivatives

The invention relates to compounds of the general formula (I) ##STR1## and physiologically acceptable salts, hydrates and bioprecursors thereof, in which

The invention relates to compounds of the general formula (I) ##STR1## and physiologically acceptable salts, hydrates and bioprecursors thereof, which show pharmacological activity as selective histamine H.sub.2 -antagonists.

Triazoleamine derivatives having histamine H.sub.2 -antagonist properties

Compounds of the formula (I) ##STR1## in which R.sub.1 and R.sub.2 each may represent hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, aralkyl, or alkyl, substituted by hydroxy, C.sub.1-3 alkoxy, amino, C.sub.1-3 alkylamino or di-C.sub.1-3 alkylamino or R.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached form an alicyclic heterocyclic ring which may be unsubstituted or may be substituted by one or more C.sub.1-3 alkyl groups or a hydroxy group and/or may contain another heteroatom are described.

Pyrimidone derivatives

The invention relates to compounds of the general formula (I) ##STR1## and physiologically acceptable salts, and hydrates thereof. The substituents are defined in the specification. The compounds show pharmacological activity as selective histamine H.sub.2 -antagonists.

1,2,4-Triazole-3-amines, their pharmaceutical compositions and method of

The invention relates to compounds of the general formula (I) ##STR1## and physiologically acceptable salts or hydrates thereof, in which the substituents are defined later in the specification. The compounds show pharmacological activity as selective histamine H.sub.2 -antagonists.

Tetrazoles, pharmaceutical use and compositions

The invention provides compounds of the general formula (I) ##STR1## and physiologically acceptable salts, hydrates and bioprecursors thereof in which the substituents are defined in the specification. The compounds of formula (I) show pharmacologically activity as selective histamine H.sub.2 -antagonists.

Amine derivatives

Compounds of the general formula (I) ##STR1## and physiologically acceptable salts, hydrates and bioprecursors thereof have been found to show pharmacological activity as selective histamine H.sub.2 -antagonists. The substituents in the compounds of formula (I) are defined in the main body of the disclosure.

1,2,4-Triazole-3-amines and their pharmaceutical use

Compounds of general formula (I) ##STR1## and physiologically acceptable salts and hydrates thereof in which R.sub.1 and R.sub.2 each represent methyl groups or together with the nitrogen atom to which they are attached form a pyrrolidino, piperidino or hexamethylenimino group;

Pharmaceutical compositions containing compounds having action on

The invention provides compounds of the general formula (I) ##STR1## and physiologically acceptable salts, hydrates and bioprecursors thereof, in which

Compounds of the general formula ##STR1## and physiologically acceptable salts, hydrates and bioprecursors thereof are disclosed, in which

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Potters Bar, United Kingdom

Roger Hayes