Centre National De La Recherche Scientifique

Commissariat a L'energie Atomique

L'air Liquide, Societe Anonyme Pour L'etude Et L'exploitation Des

Other

L'air Liquide, Soci&#xe9;t&#xe9; Anonyme Pour L'etude Et L'exploitation Des Proc&#xe9;d&#xe9;s Georges Claude

L'air Liquide, Societe Anonyme a Directoire Et Conseil De Surveillance Pour L'etude Et L'exploitation Des Procedes Georges Claude

Lars- Laboratoire D'application Et De Recherche Scientifique

L&prime;air Liquide-societe Anonyme a Directoire Et Conseil De Surveillance Pour L&prime;etude Et L&prime;exploitation Des Procedes Georges Claude

Commissariat &#xc0; L'&#xc9;nergie Atomique Et Aux &#xc9;nergies Alternatives

Roger Guilard

Frederic Barbette

Herve Chollet

Jean-louis Babouhot

Franck Denat

Henry Ledon

Panayotis Cocolios

Hervé Chollet

Ahmad Mehdi

Stéphane Brandes

Robert J Corriu

Catherine Reye

Philippe Guiberteau

Bruno Roux-Fouillet

Gilles Lagrange

Frederic Boschetti

Chloé Thieuleux

Jean-Louis Babouhot

Herv&eacute; Chollet

Christophe Jean

Jean-Michel Barbe

Michel Meyer

Brigitte Boisselier-Cocolios

Stephane Brandes

Pierre Montmeat

Veronique Migonney

Eric Pasquinet

Lionel Hairault

Bernard Brulez

Chloe Thieuleux

Claude Chuit

Véronique Migonney

Alain Tabard

Isabelle Meunier

Gabriel Canard

Arnaud Bucaille

Francois Jerome

Frédéric Barbette

G&eacute;raud Dubois

Frédéric Rascalou

Rapha&euml;l Tripier

G&eacute;rard Dubois

St&eacute;phane Brandes

François Jerome

Fr&eacute;d&eacute;ric Barbette

Géraud Dubois

Olivier Siri

Laurent Taurin

Francois Cuenot

Claude Gros

Fanny Chaux

Frédéric Boschetti

Jean-Louis Babou

Geraud Dubois

François Cuenot

An artificial ligament prosthesis which is notable in that it comprises a layer totally or partly consisting of PCL fibres. The ligament prosthesis is a biodegradable and 'biointegrable' artificial ligament which makes it possible to take away all the apprehensions and uncertainties due to non-degradable synthetic supports. It is a prosthetic structure inspired by and similar to the native tissue, which is biodegradable while being sterilisable. It can optionally be seeded in order to facilitate the formation of functional tissues with controlled cell and tissue activity, having the required mechanical properties. The prosthesis maybe slowly resorbable in order to be gradually replaced with a functional tissue identical to that of the native ligament.

Resorbable biomimetic prosthetic ligament

The present invention relates to a material notably adapted for the extraction of metal cations in an aqueous medium, comprising a solid support on which are attached polyazacycloalkane compounds having a ring including at least 4 nitrogen atoms, and wherein the nitrogen atoms of the ring are substituted with coordinating groups, which each are independently: The invention also relates to methods for preparing the aforementioned materials and to different uses thereof, notably for the extraction of Pbcations in an aqueous medium.

Materials for the solid/liquid extraction of heavy metal ions, containing supported N-functionalized polyazacycloalkanes

Material composed of a polyazacycloalkane grafted on polypropylene fibres. Process for the preparation of this material. Process for removing metal cations present in a liquid by bringing this liquid into contact with the said material.

Material comprising polyazacycloalkanes, grafted on polypropylene fibres, its process of preparation, and process for removing metal cations from a liquid

Compounds of formula (I) are disclosed.  The tetrapyrole ring in formula (I) can be substituted with a metal cation (M); R, R, Rand Rseparately represent a hydrogen atom, a C1-4 alkyl or alkyloxy radical, or a phenyl radical optionally substituted by vinyl, hydroxy, nitro, amino, bromo, chloro, fluoro, iodo, benzyloxy, or hydroxymethyl radicals; R, R, Rand Rseparately represent a hydrogen atom or a C1-4 alkyl radical; R, Rand Rseparately represent a hydrogen atom, a C1-4 alkyl or alkyloxy radical optionally substituted by a halogen, or a phenyl radical optionally substituted by vinyl, hydroxy, nitro, amino, bromo, chloro, fluoro, iodo, benzyloxy, or hydroxymethyl radicals, wherein at least one of R, R, and Ris a phenyl radical. Compounds of formula (I) bound to a silica, a sol-gel material or a mesoporous silica are useful for selective trapping of carbon monoxide.

Materials for selective trapping of carbon monoxide

The invention relates to the use of molecular tweezers as sensitive materials in chemical sensors intended to detect or assay organic compounds in the vapour state, and in particular nitro compounds. These molecular tweezers correspond to the general formula (I): in which: Fields of application: detection of explosives, control and monitoring of atmospheric pollution and of the quality of ambient air in relatively confined spaces, and monitoring of industrial sites.

Use of molecular tweezers as sensitive materials in chemical sensors for detecting or assaying organic compounds in the vapour state

A method of preparing cyclene having formula (I) from triethylenetetraamine having formula (VIII) or ethylenediamine having formula (VIII') includes a series of steps. The first series of steps (I) includes a step A (one-pot preparation of the compound having formula (IIa) from the compound having formula (VIII)), followed by a step B (transforming the compound having formula (IIa) into cyclene having formula (I)). The second series of steps (II) includes a step C (preparing the compound having formula (IIb) from the compound having formula (VIII)), followed by a step D (transforming the compound having formula (IIb) into cylcene having formula (I)). The third series of steps (III) includes a step E involving the onepot preparation of the compound having formula (IIa) from the compound having formula (VIII), followed by a step B involving the transformation of the compound having formula (IIa) into cyclene having formula (I).

Method of preparing cis-8b-methyldecahydro-2a,4a,6a,8a-tetraazacyclopenta[fg]acenaphthylene, cis-decahydro-2a,4a,6a,8a-tetraazacyclopenta[fg]acenaphthylene, cyclene and functionalised cyclenes

The invention concerns a method for preparing organic-inorganic hybrid materials with controlled porosity and functionality comprising hydrolysis and condensation polymerization of a compound of formula (I): Z-R&#x2014;Si(OR)(OR')(OR&#x2033;), with an alkaline or alkaline-earth silicate in a mol ratio of (I)/(silicate)=1:9, in the presence of a non-ionic surfactant, to form a mesoporous silica represented by Z-R&#x2014;SiO9 SiO, whereon is then anchored an organic compound, represented by (&#x394;)N&#x2014;H, comprising a &#x2014;NH&#x2014; group capable of reacting with Z, to form a functionalized mesoporous silica represented by (&#x394;)N&#x2014;R&#x2014;SiO9 SiO, which is optionally complexed with a metallic cation to form an organometallic complex. The invention also concerns the use of these materials to separate gases.

Mesoporous organic-inorganic hybrid materials for separating gases

The invention concerns a method for preparing organic-inorganic hybrid materials with controlled porosity and functionality comprising hydrolysis and condensation polymerization of a compound of formula (I): Z-R&#x2014;Si(OR)(OR')(OR&#x2033;), with an alkaline or alkaline-earth silicate in a mol ratio of (I)/(silicate)=1:9, in the presence of a non-ionic surfactant, to form a mesoporous silica represented by Z-R&#x2014;SiO9 SiO, whereon is then anchored an organic compound, represented by (&#x394;)N&#x2014;H, comprising a &#x2014;NH&#x2014; group capable of reacting with Z, to form a functionalized mesoporous silica represented by (&#x394;)N&#x2014;R&#x2014;SiO9 SiOwhich is optionally complexed with a metallic cation to form an organometallic complex. The invention also concerns the use of these materials to separate gases.

The invention relates to a method of preparing nitrogen macrocycles having formula (I). The inventive method comprises a step involving the reaction of compounds (II) and (III) in order to form a compound having formula (IV). Said compound is subsequently made to react with a compound having formula (V) in order to form a compound having formula (VI). The latter compound is then subjected to an acid treatment 

Method of preparing nitrogen macrocycles

The invention is related to a method and an installation for removal of metal cations contained in a liquid, in which said liquid is brought into contact at a temperature greater than or equal to 60&#xb0; C. with a chelating ion exchange resin formed from a polyazacycloalkane grafted on a solid support, said resin having been conditioned, previously to said contacting, at a pH of 4 to 6.

Method and installation for removal of metal cations from a liquid by resins with polyazacycloalkanes grafted on a support

Silica gel incorporating polyazacycloalkane units comprising more than six nitrogen atoms, preparation process and use

A novel compound which can be used in the field of separation and purification of gases is disclosed. The compound can be incorporated into a silica gel incorporating polyazacycloalkane structural units for separating a predetermined gas from a mixture of gases. The mixture of gases is brought into contact with a metallated hybrid gel under conditions which make possible the absorption of the gas to be separated, followed by a phase of desorption of the attached gas, and the recovery of the gas.

Silica gel incorporating polyazacycloalkane structural units

POLYAZACYCLOALKANES, TRI-, TETRA- OR PENTA-AZAMACROCYCLIC COMPLEXES, PROCESSES FOR THE PRODUCTION OF THESE SUBSTITUTED OR UNSUBSTITUTED POLYAZACYCLOALKANES GRAFTED TO A SUPPORT AND USES OF POLYAZACYCLOALKANES AND THE AFOREMENTIONED COMPLEXES

The invention concerns a method for preparing polyazacycloalkanes immobilised on a silica gel from a polyazacycloalkane of formula (A) in which: R and R represent a hydrogen atom, an alkyl radical, or a &lsqb;hetero(aryl)&rsqb;alkyl radical; W , W and W represent a radical of formula (B): &mdash;&lsqb;(CT T ) &mdash;&lsqb;N(R )&rsqb; &mdash;(CT T ) &rsqb; &mdash; such as defined in the description; R represents a hydrogen atom, an alkyl radical or a &lsqb;hetero(aryl)&rsqb;alkyl radical, provided that the polyazacycloalkane ring of the compound of formula (A) comprises not more than 30 cyclic carbon atoms, and not more than 6 cyclic nitrogen atoms. The invention is characterised in that: (a) the compound of formula (A) is reacted with a compound of formula (C): Z&mdash;R &mdash;Si(X )(X )(X ), such as defined in the description to form a compound of formula (D); (b) said compound of formula (D) is condensed on the silanol sites of a silica gel to form the immobilised polyazacycloalkane of formula (E); and (c) some ethanol sites having not reacted are, if required, protected by Z&prime;, a group protecting the hydroxyl function. The invention is useful for separating oxygen from air.

Method for preparing polyazacycloalkanes grafted on silica gel and use of grafted compounds

Novel compounds capable of carrying and releasing nitrogen oxide (NO) in a biological medium, their use for implementing a therapeutic treatment method or a diagnostic method applied to a human or animal body, and for making medicines useful for treating or preventing disorders affecting the human or animal cardiovascular, nervous, immune, renal or pulmonary system, specifically, an organometallic complex of nitrogen oxide, wherein the cationic part is of the formula (I)

Nitric oxide carriers based on polyazamacrocycle complexes

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Fontaine les Dijon, France

Roger Guilard