Becton Dickinson and Company Limited

Roger Groskopf

Min Wei

Frank Francavilla

Jamie Crawford

Lionel Vedrine

Kevin George Hetzler

Thea E Lubrecht

Charles George Hwang

Robert Banik

Ruane S Jeter

Behzad Davachi Mottahed

Michael C Ratigan

Michael A DiBiasi

Dnyanesh A Talpade

Matthew Dylan Sweeney

Michael Di Biasi

A drug delivery device is provided herein, the device including a reservoir for containing a medicament. The medicament includes a suspension of solids in a liquid carrier. The device also includes a needle having a distal end for injection into a patient, a proximal end in communication with the reservoir, and a lumen extending between the distal and proximal ends. A path is defined from the reservoir to the distal end of the needle through the lumen, the path having an inner diameter that decreases in a proximal to distal direction along at least a portion thereof. Advantageously, with the subject invention, a flow path may be defined which provides a more gradual transition in diameter from the reservoir to a distal tip of the needle. In this manner, changes in velocity of the suspension may be less abrupt than in the prior art, thus better maintaining solid particles in the suspension.

Drug delivery device for drug suspensions

In one aspect of the subject invention, a drug delivery device is provided which includes a reservoir for containing a medicament and has a proximal end and a distal end, the medicament including a suspension of solids in a liquid carrier. Further, the drug delivery device includes a needle in fluid communication with the reservoir and having a distal end for injection into a patient, and a proximal end in the reservoir. An accumulation surface is defined at least partially about the needle, distally of the proximal end of the needle. The accumulation surface defines a distally-extending indentation which is sized and shaped to collect, during use, solids that come out of suspension. Advantageously, with the subject invention, the accumulation surface allows for solids to accumulate at a location spaced from the proximal end of the needle, thereby minimizing the possibility of clogging the needle.

A tip cap is provided comprising a base portion having an upper surface and a lower surface, a body having a top wall with a non-circular cross-section extending from the upper surface, and a shaft extending from the lower surface. A syringe assembly is provided comprising a syringe comprising a barrel, and a syringe tip, extending through the barrel and a connector provided on the syringe tip. The syringe assembly further comprises a tip cap for sealingly covering the syringe tip and comprising a base portion having an upper surface and a lower surface, a body having a top wall with a non-circular cross-section extending from the upper surface, and a shaft extending from the lower surface having connection means for attaching to the syringe tip.

Syringe tip cap

In one aspect, a pen needle assembly is provided herein which includes a hub, and a needle fixed to the hub, the needle having proximal and distal ends with a lumen extending therebetween. The needle extends distally from the hub to define an exposed length between the distal end of the needle and the hub in the range of about 5.0 to 9.0 mm. The hub defines a post formed about the needle, the post having a distally-facing first skin engaging surface. The exposed length of the needle extends distally from the first skin engaging surface. The hub also defines a distally-facing second skin engaging surface which at least partially circumscribes the first skin engaging surface. The second skin engaging surface being located proximally of the first skin engaging surface. Advantageously, a pen needle assembly is provided having two skin engaging surfaces which provide stability in achieving subcutaneous injections.

Pen needle assembly for delivering drug solution

A drug delivery device is provided herein which includes a tubular body defining an opening. A drug cartridge is also provided having a distal end larger in diameter than the opening. With the drug cartridge being inserted into the tubular body in a use position, the distal end of the drug cartridge is located at least partially externally of the tubular body. The medical pen injector of the subject invention further includes an adaptor engageable with the body. The adaptor encompasses the distal end of the drug cartridge with the drug cartridge being in the use position. The adaptor includes features for mounting a needle assembly thereto. Advantageously, with the subject invention, a drug cartridge having a large distal end may be accommodated with a drug delivery device, e.g., a pen injector type device.

Drug delivery device having cartridge with enlarged distal end

In one aspect, a pen needle assembly is provided herein which includes a hub, and a needle fixed to the hub, the needle having proximal and distal ends with a lumen extending therebetween. The needle extends distally from the hub to define an exposed length between the distal end of the needle and the hub in the range of about 5.0 to 9.0 mm. The hub defines a post formed about the needle, the post having a distally-facing first skin engaging surface. The exposed length of the needle extends distally from the first skin engaging surface. The hub also defines a distally-facing second skin engaging surface which at least partially circumscribes the first skin engaging surface. The second skin engaging surface being located proximally of the first skin engaging surface. Advantageously, with the subject invention, a pen needle assembly is provided having two skin engaging surfaces which provide stability in achieving subcutaneous injections.

Pen needle assembly for delivering drug solutions

A cartridge or injector for holding and mixing a medical product is provided herein including a tubular body having a cylindrical wall having first and second opposing ends. The wall includes inner and outer surfaces with the inner surface having a generally constant cross-section along at least a drug mixing area. A first stopper is slidably disposed within the wall between the first and second ends, the first stopper defining a liquid-tight seal with the inner surface. A second stopper is slidably disposed within the wall between the first stopper and the first end, the second stopper defining a liquid-tight seal with the inner surface. A flexible insert is disposed at or in proximity to the second end, the insert forming a liquid-tight seal with the wall, the insert being pierceable by a medical needle or other piercing instrument. A rigid retainer is fixed to the wall having an opening therein for providing access to the insert for piercing by a medical needle. The insert extends into the retainer and forms a liquid-tight seal across the opening. Advantageously, with the subject invention, a reconstitution assembly may be provided which has a sufficiently large distal opening during assembly which allows a dry component to be introduced into the device in a dry state.

Cartridge for powder and liquid drug

A method of fusing a component to a sterilized storage or delivery device formed of a cyclic olefin polymer which includes forming the storage or delivery device from a cyclic olefin polymer, forming a second member or component having at least a surface layer formed of the second polymer, wherein the Hansen relative energy distance Ra/Ro of the second polymer relative to the cyclic olefin polymer is equal to or less than 0.7, applying the second member to the storage or delivery device, and heating the assembly to the sterilization temperature, thereby causing the second polymer to chemically interact with the cyclic olefin polymer, fusing the second component to the storage or delivery device. The preferred embodiment of the invention is a medical container, such as a vial, wherein the vial is formed of a cyclic olefin polymer and the cap, closure or collar is formed of a second polymer heat fused to the vial or container.

Method of fusing a component to a medical storage or transfer device and container assembly

A medical device for delivering a medicament to a patient. The device includes a syringe barrel with a plunger having a hollow front end and a stopper positioned over the plunger front end to seal the plunger front end. The stopper is movably inserted in the barrel to expel medicament in the barrel. A needle cannula is fixed to a needle cannula hub and is movable between an initial position in which the forward tip of the needle cannula is exposed and a retracted position in which the forward tip is contained within the medical device. A plug seal releasably secures the needle cannula hub to an end of the barrel, and a hub adapter secures the plug seal to the barrel end. A cutter positioned on the plunger pierces the stopper when the stopper is pressed against the plug seal to open the hollow front end of the plunger. The plunger also engages the plug seal to allow the needle cannula hub to move, via an urging member, to the retracted position through the front end of the plunger.

Syringe having a retractable needle

A medical device includes a syringe assembly and a shield system for delivering medicament to a patient. The syringe assembly includes a barrel defining a medicament reservoir, a needle cannula coupled to the barrel and in fluid communication with the reservoir, a plunger having a stopper positioned in the reservoir and a thumb pad for moving the plunger in the reservoir. The shield system has a shield coupled to a forward end of the barrel, the shield being movable from a first position disposed from the needle cannula tip to a second position during insertion of the needle into a patient and movable from the second position to a third position covering the needle cannula tip after the needle cannula is removed from the patient. An urging member urges the shield to the third position upon removal of the needle cannula from the patient.

Safety shield system for a syringe

A medical device for delivering medicament to a patient including a syringe assembly, a shield body, a retainer and an urging member. The syringe assembly includes a barrel defining a reservoir for medicament, a needle cannula coupled to the barrel and in fluid communication with the reservoir, a plunger having a stopper positioned in the reservoir and a thumb pad for moving the plunger in the reservoir. The syringe barrel is movable within the shield body between a first position exposing the forward tip of the needle cannula, and a second position where the tip of the needle cannula is in the shield body. A retainer secures the syringe barrel in the first position. An urging member urges the syringe barrel from the first position toward the second position upon interaction with the thumb pad and upon the release of pressure applied to the thumb pad.

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Saddle Brook, NJ, United States of America

Roger Groskopf