Commissariat a L'energie Atomique

Centre National De La Recherche Scientifique

Commissariat &#xc0; L'&#xc9;nergie Atomique Et Aux &#xc9;nergies Alternatives

Roger Genet

Jean-Luc Pernodet

Muriel Gondry

Sylvie Lautru

Pierre Fromageot

The invention concerns novel isolated natural or synthetic polynucleotides and polypeptides coded by said polynucleotides, involved in the synthesis of diketopiperazine derivatives, vectors comprising said polynucleotides, micro-organisms transformed with said polynucleotides, uses of said polynucleotides and said polypeptides, as well as methods for the synthesis of diketopiperazine derivatives, including cyclodipeptides and diketopiperazine derivatives 3- and 6-substituted by &#x3b1;,&#x3b2;-unsaturated amino acid side chains.

Polynucleotides and polypeptides coded by said polynucleotides involved in the synthesis of diketopiperazine derivatives

The invention concerns novel isolated natural or synthetic polynucleotides and polypeptides coded by said polynucleotides, involved in the synthesis of diketopiperazine derivatives, vectors comprising said polynucleotides, micro-organisms transformed with said polynucleotides, uses of said polynucleotides and said polypeptides, as well as methods for the synthesis of diketopiperazine derivatives, including cyclodipeptides and diketopiperazine derivatives 3- and 6- substituted by &#x3b1;,&#x3b2;-unsaturated amino acid side chains.

Purified enzymatic preparation derived from Chromobacterium violaceum, having a dehydrogenase activity, method for preparing it and its use in the production of .alpha.,.beta.-dehydrotryptophanyl-peptides. The said method for preparing .alpha.,.beta.-dehydrotryptophanyl-peptides and .alpha.,.beta.-dehydrotryptophanyl-proteins is characterised in that one brings into contact:

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Limours-en-Hurepoix, France

Roger Genet