California Institute of Technology

Roger G Kern

Gil F Richards

Gene R Petersen

Ara N Chutjian

David A Kidwell

Murray R Darrach

Frederick W Mintz

Provided are methods and systems for rapidly and effectively characterizing a cell as belonging to a particular genus, species, strain, or having a particular phenotype. The methods and systems utilize mass spectrometry and low-energy negative ionization to detect cell surface markers indicative of a particular cell.

Detector using mass spectroscopy for characterization of biological community

The present invention is an apparatus and a method of detecting a chemical released by perspiration, typically through sweat and broadcasting the detection to a receiver. The chemical may be a drug of abuse. The device which is attached to the skin of a subject contains labeled antibodies or label containing microspheres attached to antibodies. The labeled antibodies are bound to solid phase drug via antigen-antibody interaction. These labeled antibodies are displaced from the solid phase support to which they are bound by free drug molecules in the perspiration. These labeled antibodies then migrate through a spacer layer and are trapped by a layer containing a suitable selective binding material. The label is illuminated or excited by a light source and detected by a photodetector. The signal can be recorded, or transmitted to a remote radio monitor.

Real-time biochemical assay telemetering system

An analog of sialic Lewis antigen prepared from native capsular polysaccharide of Klebsiella 63 bacteria.

Synthetic analog of sialic Lewis antigen from bacterial capsular

Structurally altered capsular polysaccharides are produced by mutant bacteria. These polysaccharides are isolated by selecting a wild type bacterial strain and a phage producing degradative enzymes that have substrate specificity for the capsular polysaccharides produced by the wild type bacteria. Phage-resistant mutants producing capsular polysaccharides are selected and the structurally altered capsular polysaccharide is isolated therefrom.

Growing community of inventors

Pasadena, CA, United States of America

Roger G Kern