Noville, Inc.

Beecham Plc

Firmenich Sa

Roger E Stier

John Zanone

James D Vidra

William H Dunn

Daniel Carey

Jacqueline Christine Lucia

Douglas P Fritz

Bernard Misek

The invention pertains to cooling agents comprising N-substituted p-menthane-3-carboxamides, menthyl acetate and solubilizer, and methods for making the cooling agents. The invention also concerns pharmaceutical compositions comprising the cooling agents, including tablets, suspensions and liquid solutions having active pharmaceutical agents for treating upper gastrointestinal tract distress, and methods for treating upper gastrointestinal tract distress in humans.

Cooling agents, pharmaceutical compositions having cooling agents and processes for making and using same

The invention relates to oral care compositions such as toothpaste, gels, tooth powders, mouthwashes, mouth rinses, gums, such as chewing gum, mouth sprays and lozenges comprising diglycerol. The diglycerol is used as a humectant in the compositions. The compositions may further comprise water, flavoring agents, active compounds, emulsifier, alcohol, sweeteners, thickening agents, surfactants, suspending agents, astringent and toning drug extracts, flavor correctants, abrasives or polishes, deodorizing agents, preservatives, flavoring buffers, whitening agents, wound-healing and inflammation inhibiting substances, colorants, dyes, pigments, abrasives, polishes, antimicrobial agents, pH buffers and other additives and fillers.

Chewing gum compositions comprising diglycerol

The invention relates to oral care compositions such as toothpaste, gels, tooth powders, mouthwashes, mouth rinses, gums, mouth sprays and lozenges comprising diglycerol. The diglycerol is used as a humectant in the compositions. The compositions may further comprise water, flavoring agents, active compounds, emulsifier, alcohol, sweeteners, thickening agents, surfactants, suspending agents, astringent and toning drug extracts, flavor correctants, abrasives or polishes, deodorizing agents, preservatives, flavoring buffers, whitening agents, wound-healing and inflammation inhibiting substances, colorants, dyes, pigments, abrasives, polishes, antimicrobial agents, pH buffers and other additives and fillers.

Oral care compositions comprising diglycerol

Cosmetic compositions, particularly solid or gel stick type deodorant compositions, comprising a base solvent system having at least diglycerol, and optionally polyhydric alcohols, and water and gelled with alkali metal salts of saturated fatty acids. The compositions may further comprise monohydric alcohols, surfactants, emollients, fatty alcohols, stabilizing agents, antimicrobial and antibacterial agents, cooling agents, fragrance, dyes and the like. The compositions exhibit improved clarity, enhanced and stronger fragrance impact, and a directional increase in fragrance longevity.

Deodorant compositions comprising diglycerol

Oral care compositions comprising chlorine dioxide and excipients, including flavoring agents and ethoxylated hydrogenated castor oil having ethoxylation numbers from about 35 to about 60. The flavoring agents become bound to the hydrophobic end of the ethoxylated hydrogenated castor oil molecule and become encapsulated within the molecule as the hydrophilic end of the ethoxylated hydrogenated castor oil wraps around the flavoring agent. The flavoring agent does not undergo oxidation. The oral care compositions do not develop either a chlorine odor or yellowing discoloration. The oral care compositions can be packaged, stored, sold and used in a single package.

Oral care compositions comprising stabilized chlorine dioxide

The invention concerns a process for making personal care compositions and opacifying agents, and corresponding products, having a stable cloudy and milky appearance. The components are processed in a specific sequence in which titanium dioxide is added after thickening agent which comprises a hydrophilic colloid. The composition may, optionally, comprise calcium lactate, calcium lactate salts and combinations thereof. The products, and process, may also comprise the addition of other components such as filler, additives, colorants, cooling agents, warming agents, numbing agents, additional flavorings, active compounds, pharmaceutical actives and excipients or finished bases.

Process for making personal care compositions comprising titanium dioxide and personal care compositions made by the process

An oral hygiene composition containing eucalyptol and a zinc salt, wherein the harsh taste or burn sensation ordinarily imparted by the eucalyptol and the astringency ordinarily caused by the zinc salt are abated or eliminated by effective amounts in the composition of a taste receptor blocker, preferably in combination with a three component flavor system containing at least one spice, at least one sweetener and at least one fruity note. The taste receptor blocker is preferably a hydrogenated, ethoxylated glycerol ester which has the mouth feel characteristic of a fat but which has a much higher degree of solubility and hence improved clarity (ie., reduced cloudiness) for the composition.

Oral hygiene compositions which mask the burn sensation and the astringency of eucalyptol and zinc

An anti-caries aqueous solution, which comprises an aqueous solution containing an anti-caries effective amount of TiF.sub.4 and a chelating agent in an amount effective to stablilize the TiF.sub.4, said solution having a pH of at least about 3.5.

Aqueous solution containing TiF.sub.4 and chelating agent

An extrudable, shape-retaining aqueous toothpaste which comprises an anti-caries effective amount of TiF.sub.4, a dental polishing or abrasive agent, a chelating agent in an amount effective to stabilize the TiF.sub.4, and an aqueous dental vehicle, said aqueous toothpaste having a pH of at least about 3.5.

Hydrous toothpaste containing TiF.sub.4 and chelating agent

A dentifrice containing an anticaries agent and an abrasive is produced to which has been added at least one color indicator which, when the user brushes his or her teeth with the dentifrice, results in a color change in the dentifrice within the user's mouth after a predetermined period of brushing time has elapsed for the purpose of indicating to the user that he or she has brushed his or her teeth a sufficient length of time.

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Clifton, NJ, United States of America

Roger E Stier