Smithkline Corporation

Roger C Parish

William D Kingsbury

Clifton A Baile

Richard D Hedde

William V Chalupa

Supplemented livestock feedstuffs and methods of feeding using as active ingredient a chemical compound having histamine H.sub.2 antagonist activity improve the utilization of food by meat producing animals. A specific compound of use as the active ingredient is metiamide.

Livestock feed and method for improving food utilization

New 2,3-bis-(3-acyl-2-thioureido)-pyridines having anthelmintic activity are prepared by reacting a diaminopyridine with acylthiocyanates.

2,3-Bis-(3-lower alkanoyl-2-thioureido)-pyridines

2,3-Bis-(3-acyl-2-thioureido)-pyridines

Compositions and methods for inducing polyphagia or eating in meat producing animals comprise administering orally or preferably by injection an effective but nontoxic subpharmacodynamic quantity of a benzhydryl ether active ingredient. Preferred active ingredients are tropine benzohydryl ether, 3-quinuclidinyl benzohydryl ether or their nontoxic acid addition salts.

Methods for improving the feed intake of meat producing animals

New 2,3-bis(3-acyl-2-thioureido)-pyridines having anthelmintic activity are prepared by reacting a diaminopyridine with acylthiocyanates.

Compositions and methods for improving the feed efficiency of ruminant animals comprise using dithiooxamide as an active ingredient. Dithiooxamide inhibits both methanogenesis and microbial degradation of amino acids in the rumen.

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King of Prussia, PA, United States of America

Roger C Parish