Merck + Co., Inc.

Roger C Olewinski, Jr

Thomas R Verhoeven

Michel M Chartrain

Neal C Connors

Paul J Reider

George M Garrity

Chris H Senanayake

F Edward Roberts

Brian Heimbuch

Jinyou Zhang

Randolph L Greasham

Francis P Gailliot

Barbara A Jackey

Chanyong Lee

Barry C Buckland

A process is disclosed that bioconverts indene to (1S)-amino-(2R)-indanol substantially free of any of its stereoisomers, by the action of a strain of P. putida or Rhodococcus sp., followed by various chemical step(s), e.g., chiral specific crystallization, treatment with strong acid in the presence of acetonitrile.

Conversion of indene to (1S)-amino-(2R)-indanol free of any

A process is disclosed that quantitatively bioconverts indene to (1S,2R)-indene oxide and (1S,2R)-indandiol, by the action of fungal haloperoxidase followed by various chemical step(s), e.g., adjusting the pH.

Quantitative conversion of indene to (1S,2R) indene oxide and

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Milltown, NJ, United States of America

Roger C Olewinski, Jr