Astra Pharmaceuticals Limited

Fisons Ltd.

Astra Zeneca U.k. Limited

Roger C Brown

Roger Victor Bonnert

Francis Ince

David R Cheshire

John Dixon

Hugh Cairns

Peter A Cage

John Mann

Richard Hazard

Anthony R Payne

Garry Pairaudeau

David H Robinson

Rodney A Brown

Stephen E O'Connor

Compounds

A compound of formula I, including optical isomers thereof, wherein X represents --SO.sub.2 NH-- or --NHSO.sub.2 --, p, q and r independently represent 2 or 3, Y represents thienyl optionally substituted by alkyl or halogen, or phenylthio- or phenyl optionally substituted by alkyl or halogen, and each R independently represents H or alkyl and pharmaceutically acceptable salts, esters and amides thereof

Benzothiazolone derivatives

A compound of formula I, including optical isomers thereof, ##STR1## wherein X represents --SO.sub.2 NH-- or --NHSO.sub.2 --,

Intermediates for making benzothiazolone derivatives

Biologically active benzothiazolone ethanamines

There are disclosed compounds of formula I,

7-(2-aminoethyl) benzothiazolones

There are described compounds of formula I, ##STR1## in which Y is S, O or NR.sub.9,

1,3,4-thiadiazoles

There are described compounds of formula I, ##STR1## in which R.sub.5 to R.sub.8 may be a variety of substituents, or an adjacent pair of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a chain

N-Substituted-quinolin-4-one-2-carboxic acid derivatives

The substituted theophyllines of the formula: ##STR1## (wherein R.sup.1, R.sup.2 and R.sup.3, which may be the same or different, each represent alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenyl or phenylalkyl of 7 to 10 carbon atoms, each of which may be unsubstituted or substituted by one or more hydroxy groups, alkoxy or alkylthio groups of 1 to 4 carbon atoms, halogen atoms, cyano groups, nitro groups, carboxy groups, alkoxycarbonyl groups of 2 to 5 carbon atoms, amino groups, alkylamino groups of 1 to 4 carbon atoms or dialkylamino groups of 2 to 8 carbon atoms, or when the group is phenyl or phenylalkyl, by one or more alkyl groups of 1 to 4 carbon atoms;

Substituted theophylline compounds

There are described compounds of formula I, ##STR1## in which R.sub.3 represents hydrogen, or alkyl C 1 to 6,

Tricyclic mono-chromone-2-carboxylic acids

There are described compounds of formula I, ##STR1## in which R.sub.3 represents hydrogen, or alkyl C 1 to 6, R.sub.5 represents hydrogen, hydroxy, alkoxy C 1 to 6, alkanoyloxy C 2 to 6, alkenyloxy C 2 to 6, nitro, -NR.sub.1 R.sub.2, halogen, alkyl C 1 to 6, hydroxy-alkyl C 1 to 6, or hydroxy-alkoxy C 1 to 6,

There are described compounds of formula I, ##STR1## in which R.sub.5 to R.sub.8 may be a variety of substituents, OR AN ADJACENT PAIR OF R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a chain --COCH.dbd.C(COOH)NRh--, Or one of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a group of formula II, ##STR2## in which Ra, Rb and Rc have the same significances as R.sub.5, R.sub.6, R.sub.7 and R.sub.8, X is an optionally interrupted or substituted hydrocarbon chain, Rg and Rh, which may be the same or different are each alkyl, alkenyl, phenyl-alkyl, alkanoyl, benzoyl or phenylalkanoyl, Or Rg and R.sub.8 and/or Rh and Rc in formula II, together form a chain --(CH.sub.2).sub.n --, and n is 2, 3 or 4. There are also described processes for making the compounds and pharmaceutical, e.g. anti-allergic, compositions containing the compounds.

Growing community of inventors

Loughborough, United Kingdom

Roger C Brown