Marina Biotech, Inc.

Pfizer Corporation

Pfizer Products Inc.

Roger C Adami

Michael E Houston, Jr

Steven C Quay

Mary Gallagher Prieve

Pierrot Harvie

Shaguna Seth

Kathy L Fosnaugh

Renata Fam

Michael V Templin

Rachel E Johns

Barry A Polisky

Frederick David

Julia Ann Wood

Jaya S Giyanani

Michael Houston

Lipopeptide compounds having a central peptide HHHHHKHHHKKKHKHKKK (SEQ ID NO:15) and a lipophilic group attached to each terminus of the peptide, and salts thereof. The lipopeptides are useful for forming pharmaceutical compositions for delivery of nucleic acid agents, such as siRNA and mdRNA agents, as well as in methods for treating the signs and symptoms of disease.

Lipopeptides for delivery of nucleic acids

This disclosure provides a range of tyrosine amino acid lipid compounds and compositions useful for drug delivery, therapeutics, and the diagnosis and treatment of diseases and conditions. The amino acid lipid compounds and compositions can be used for delivery of various agents such as nucleic acid therapeutics to cells, tissues, organs, and subjects.

Tyrosine-based lipids for delivery of therapeutics

This disclosure provides a range of amino acid lipid compounds and compositions useful for drug delivery, therapeutics, and the diagnosis and treatment of diseases and conditions. The amino acid lipid compounds and compositions can be used for delivery of various agents such as nucleic acid therapeutics to cells, tissues, organs, and subjects.

Arginine-based lipids for delivery of therapeutics

Lipopeptide compounds with a central peptide and having lipophilic groups attached at each terminus, and salts and uses thereof. The lipophilic groups can be derived from a naturally-occurring lipid, or can be a C(1-22)alkyl, C(6-12)cycloalkyl, C(6-12)cycloalkyl-alkyl, C(3-18)alkenyl, C(3-18)alkynyl, C(1-5)alkoxy-C(1-5)alkyl, or a sphinganine, or (2R,3R)-2-amino-1,3-octadecanediol, icosasphinganine, sphingosine, phytosphingosine, cis-4-sphingenine. The compounds can be used in compositions to deliver active agents to cells, including interfering-RNA agents and antisense RNAs.

Amino acid lipids and uses thereof

The present invention is directed to pharmaceutical compositions containing a therapeutically effective amount of an Active Pharmaceutical Ingredient ('API'), a pharmaceutically acceptable cyclodextrin and a pharmaceutically acceptable preservative. The invention is also directed to pharmaceutical compositions of the compounds of Formula (I) wherein Ris selected from the group consisting of methyl, ethyl, isopropyl, sec-butyl and tert-butyl and a pharmaceutically acceptable cyclodextrin and preservative. Formula (I): In particular, the invention is directed to pharmaceutical compositions of the compound of Formula 1, and a pharmaceutically acceptable cyclodextrin and a preservative. 

Antimicrobial preservatives to achieve multi-dose formulation using beta-cyclodextrins for liquid dosage forms

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Bothell, WA, United States of America

Roger C Adami