The Dow Chemical Company

Roger B Hornby

Robert D Mahoney

David J Forgach

Jee I Kau

Gordon E Fleig

Melvin Rothberg

Jeffrey D Michalowski

Ernest A Sharer

Bill C Sager

Hollow fiber structures for culturing mammalian cells in an agitated media are disclosed. These hollow fibers have a cylindrical wall surrounding a lumen preferably open at opposite ends of the fiber and have a length along the axis parallel to the lumen of not more than 5 centimeters. Hollow fiber structures which have their exterior surface coated to prevent cell attachment and growth thereon are also disclosed.

Growth of cells in hollow fibers in an agitated vessel

This invention consists of a composition useful for preparing a cellulose ester membrane comprising (1) a cellulose ester, (2) glycerol monoacetate, glycerol diacetate, glycerol triacetate, or mixtures thereof, and (3) optionally glycerol, wherein the cellulose ester membrane prepared from said composition is useful for a membrane liquid separation process such as microfiltration, ultrafiltration, dialysis, or reverse osmosis. In another aspect, this invention is an improved process for using said composition to prepare a cellulose ester membrane by forming a mixture of said composition, heating the mixture to a temperature at which the mixture becomes a homogeneous fluid, and extruding, molding, or casting the homogeneous fluid into a membrane. Another aspect of this invention consists of a cellulose ester membrane wherein the fabricated membrane contains glycerol monoacetate, glycerol diacetate, glycerol triacetate, or mixtures thereof, and optionally glycerol.

Compositions useful for preparing cellulose ester membranes for liquid

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Sanford, MI, United States of America

Roger B Hornby