Codexis, Inc.

Imperial Chemical Industries Limited

Exxonmobil Research and Engineering Company

Dsm IP Assets B.v.

Clea Technologies B. V.

Roger Arthur Sheldon

John M Gruber

Lisa Marie Newman

Gjalt W Huisman

S Christopher Davis

John H Grate

David R Gray

Steven K Ma

Li A Wang

Xiyun Zhang

Jack S Liang

Benjamin Mijts

Michael D Clay

James Joseph LaLonde

Jagadeesh Mavinahalli

Sheela Muley

Jeffrey Colbeck

John D Munger, Jr

Jun Zhu

Jian Ding

Jihad Mohammed Dakka

Stuart Leon Soled

Sabato Miseo

Jose G Santiesteban

Joseph Ernest Baumgartner

Michiel Christian Alexander Van Vliet

James LaLonde

Xavier Baucherel

Vytautas-Juozapas Kajetono Svedas

Dorel Teodor Guranda

Frederik Rantwijk Van

Lukas Michaël Langen Van

Menno Jort Sorgedrager

Bernadett Kondor

A non-leachable, crosslinked, on a nanometer scale formed magnetic enzyme aggregate, consisting of a non-layered, hybrid nano-composite of functionalized magnetic nanoparticles and aggregated enzyme particles, is described. The magnetic enzyme aggregate can have a high enzyme content, of up to 99%. The high enzyme content allows the use on a small scale, such as for example in a fluidized bed, of the magnetic enzyme aggregate. Also, a process for the preparation of the present magnetic enzyme aggregate is described.

Non-leachable magnetic cross-linked enzyme aggregate

The present disclosure provides substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M', and Rare as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.

Biocatalytic processes for the preparation of stereomerically pure fused bicyclic proline compounds

The present disclosure provides monoamine oxidase enzymes and methods of their use in biocatalytic processes for the preparation of substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M', and Rare as described herein.

Biocatalytic processes for the preparation of substantially stereomerically pure fused bicyclic proline compounds

The present invention provides methods and compositions for preparing 4-substituted 3-hydroxybutyric acid derivatives by halohydrin dehalogenase-catalyzed conversion of 4-halo-3-hydroxybutyric acid derivatives. The present invention further provides methods and compositions for preparing 4-halo-3-hydroxybutyric acid derivatives by ketoreductase-catalyzed conversion of 4-halo-3-ketobutyric acid derivatives The present invention also provides methods and compositions for preparing vicinal cyano, hydroxyl substituted carboxylic acid esters.

Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives

The present invention is related to a hydrocarbon oxidation process. The process comprises bringing one or more hydrocarbons into contact with a source of oxygen in the presence of a radical initiator and a catalyst. The catalyst comprises an organic metal complex located on a catalyst support, and is obtained by partial decomposition of the organic metal complex. For example, the process can be used to produce dimethyl carbonate from dimethoxy methane. The invention is also related to a partially decomposed catalyst that comprises a silica support and an organic metal complex, wherein at least 5% of the organic compound remains in the catalyst. The organic metal complex comprises an organic compound and a metal-based compound wherein the metal is selected from copper, nickel, and combinations thereof. The invention is also related to a process for manufacturing of a catalyst comprising mixing L-arginine, a Cu-based compound, water, and optionally another metal-based compound to form a solution; impregnating the solution onto a silica support to form a catalyst precursor; and partially decomposing the L-arginine to form the catalyst so that at least 5% of L-arginine remains in the catalyst.

Partially decomposed catalyst and hydrocarbon oxidation processes using the same

Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives and vicinal cyano, hydroxy substituted carboxylic acid esters

The present invention provides methods and compositions for preparing 4-substituted 3-hydroxybutyric acid derivatives by halohydrin dehalogenase-catalyzed conversion of 4-halo-3-hydroxybutyric acid derivatives. The present invention further provides methods and compositions for preparing 4-halo-3-hydroxybutyric acid derivatives by ketoreductase-catalyzed conversion of 4-halo-3-ketobutyric acid derivatives.

The invention provides a process for the catalytic oxidation of an alkane, which comprises contacting the alkane with a source of oxygen in the presence of a catalyst comprising a compound of the formula (2) where Rand Rindependently represent a hydrogen atom, a halogen atom, an alkyl group, an aryl group, a cycloalkyl group, a hydroxyl group, an alkoxy group, a carboxyl group, an alkoxycarbonyl group, or an acyl group, or Rand Rmay together form a double bond or an aromatic or non-aromatic ring; Y represents an oxygen atom or a sulfur atom; X represents an oxygen atom or a hydroxyl group; m denotes an integer of 0 to 4; and n denotes an integer of 1 to 3. Compounds in accordance with formula (2) possess good catalytic properties, such that when they are employed in a process in accordance with the present invention, they are capable of activating a source of oxygen and promoting the oxidation of an alkane at mild reaction temperatures.

Catalytic oxidation process

Method for the preparation of an enantiomerically enriched acylated amine wherein a phenylacetic acid derivative is brought into contact with a mixture of enantiomers of an amine HNCRRR, in which R, R, Rare not equal to each other and each independently stand for H, CN, a whether or not substituted (cyclo)alkyl, ary-, alkylaryl or arylalkyl group, whether or not cyclic heteroalkyl or heteroaryl group with one or more N, O or S atoms or in which Rand R(and R) together with the C-atom to which they have been bound form a (bi)cyclic group that optionally contains one or more N, O of S atoms, in the presence of a Pen-G acylase derived from And method for the preparation of enantiomerically enriched amine of formula HNCRRR, in which R, R, Rare as defined above, wherein an acylated amine is brought into contact with a Pen-G acylase originating from. Preferably enantiomerically enriched phenylglycine amide or an ester of p-hydroxyphenylglycine is applied as phenylacetic acid derivative.

Method for the preparation of enantiomerically enriched amines

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Hoog Keppel, Netherlands

Roger Arthur Sheldon