Mallinckrodt, Inc.

University Of Zürich

Paul Scherrer Institut

Solidago Ag

Zurich, Universtitat

Roger Alberto

Roger Schibli

Pascal Jean-Marie Hafliger

Stefan Mundwiler

Joseph E Bugaj

Lukas Kromer

Robert Waibel

Fabio Zobi

Henrik Braband

Jae Kyoung Pak

Susanne Barbara Kunze

Hector Knight Castro

Hans-Jörg Treichler

Martin T Küenzi

Jakob Nüesch

Dave R Van Staveren

Andr&eacute; Egli

The present invention relates to new rhenium compounds of formula (I) 

Carbon monoxide releasing rhenium compounds for medical use

A method for synthesizing a complex having the formula: [L3MO3]&#x2033; wherein Lrepresents a tridentate ligand, M represents a metal selected from Tc an Re, and n is a charge from &#x2212;2 to +1, the method comprising: a) reaction of pertechnetate or perrhenate with a reducing agent and L, or b) reaction of pertechnetate or perrhenate with a Lewis acid and L, wherein the synthesis (a) or (b) is carried out in an aqueous medium.

Metal complexes

The invention relates to molecules for treatment and diagnosis of tumors and malignancies, comprising a tumor seeking biomolecule, which is coupled to an intercalating moiety, which is capable of complexing a metal, which metal is preferably a radioactive metal, to the use of these molecules and to therapeutic and diagnostic compositions containing them.

Combination of intercalating organometallic complexes and tumor seeking biomolecules for DNA cleavage and radiotherapy

The present invention relates to novel histidine derivates that can be used for the labeling of biomolecules with radioactive metal tricarbonyls. The new derivatives have a histidine that is derivatized at the Nand at least protected at the Nand optionally at the N; or derivatized at the Nand at least protected at the Nand optionally at the N; or derivatized at the Nand Nand at least protected at the Nand optionally at the N; or derivatized at the N; or derivatized at the N; or derivatized at the Nand N; or at least protected at the Nand optionally at the N.

[object Object]

The present invention relates to a metal complex of the general formula M(L), wherein each L is independently selected and represents a ligand and at least one L is vitamin B(cyanocobalamin) or a derivative thereof bound through the nitrogen atom of its cyanide group to M, which is an element selected from the transition metals, thus, forming a M-NC-[Co] moiety with [Co] representing vitamin Bwithout cyanide and wherein n is 1, 2, 3, 4, 5 or 6. The complex can be prepared by mixing a precursor molecule with vitamin B. The metal complexes can be used for radiodiagnostics, chemotherapy and radionuclide therapy. 

The invention relates to cobalamin derivatives having no or low binding affinity to the transport protein transcobalamin II (TCII) and retaining activity as a vitamin B12 substitute, optionally carrying a therapeutic and/or diagnostic agent, such as a radioactive metal. These compounds have a much reduced accumulation rate in blood and benign organs, such as kidney and liver, compared to the accumulation rate in neoplastic tissues, and are more rapidly eliminated from blood. The invention further relates to a method of diagnosis and a method of treatment of a neoplastic disease or an infection by microorganisms in a mammal by exposing the mammal to a period of a vitamin B12 free diet, and subsequently applying a cobalamin derivative of the invention carrying a diagnostic and/or therapeutic agent. By selecting cobalamin derivatives acting as vitamin B12 substitutes, the risk of the formation of resistant off-spring in neoplastic tissue is much reduced.

Cobalamine derivatives useful for diagnosis and treatment of abnormal cellular proliferation

The present invention relates to kits including compounds that may be used as a carbon monoxide source and optionally as a reducing agent in the preparation of transition metal carbonyl complexes.

Kits for preparing transition metal carbonyl complexes

The present invention relates to compounds that have a novel use as a carbon monoxide source and optionally as a reducing agent in the preparation of transition metal carbonyl complexes. The compounds are in general compounds of formula (I) wherein X, Xand Xare the same or different and either a Lewis base or hydride and Y is a sigma donating group. The invention furthermore relates to a method for the preparation of borane carbonate and to the use of HBCO as a reducing agent. 

Carbon monoxide source for preparation of transition-metal-carbonyl-complexes

The invention relates to novel aminocarboxylate ligands that are suitable for complexing with a radionuclide, and are useful as imaging agents for diagnostic purposes. In accordance with the present invention, a method of preparing a compound of formula (I): fac-[M(CO)(OH)], wherein M is Mn,Tc,Re orRe, involves reacting a metal in permetallate form with carbon monoxide and a reducing agent, wherein a mixture of a basic borate buffer and a reducing agent soluble in water but not substantially decomposed by water is solved in a water containing solvent system containing a solution of the metal in permanganate, pertechnetate or perrhenate form in the presence of carbon monoxide. The compound of formula (I) can be reacted with a ligand Lto form a compound of formula (II): fac-[M(CO)(X)L], wherein M is as defined above Lis a multidentate ligand, and n is a charge of the ligand Lincreased with one + charge. The invention also is directed to novel compounds, and kits for carrying out the disclosed methods.

Group (VII) transition-metal complexes with multidentate aminopolycarboxylate ligands and a kit for producing them

The invention relates to a method of preparing facial metal tricarbonyl compounds and further coordinated facial metal tricarbonyl compounds in water or an aqueous medium. The invention further relates to the use of said facial metal tricarbonyl compounds in the labelling of biologically active substrates and other ligands, and to a kit for preparing a facial metal tricarbonyl compound or further coordinated facial metal tricarbonyl compounds.

Growing community of inventors

Winterthur, Switzerland

Roger Alberto