University of Saskatchewan

Biostar, Inc.

Roger A Pierson

Gregg Patrick Adams

John G Manns

Ildiko Badea

Maria Jimena Yapura

An intravaginal device that provides biologically active circulating concentrations of an aromatase inhibitor for at least about of 4 days. Liposome-based and a wax-based formulations were used to assess letrozole diffusion through bovine vaginal mucosa in a diffusion chamber study. The wax-based vehicle was selected for further development of a letrozole intravaginal device based on its steady release rate. The addition of a letrozole-containing gel coating improved initial absorption and hastened the increase on plasma concentrations of the active ingredient, while the letrozole-containing wax-based vehicle maintained prolonged delivery from the intravaginal device.

Aromatase inhibitor-releasing intravaginal device

Described herein are methods for synchronizing ovulation in a herd, inducing superovulation in a single animal, and improving frequency of successful implantation and development of fertilized ova.

Methods of administering an aromatase inhibitor, prostaglandin and GnRH for regulating ovulation in cattle

Ultrasonography together with computer analysis tools are used to obtain measurements of gonadal density and size in male livestock, and particular in immunologically castrated boars in a slaughterhouse. These measurements are compared with reference thresholds with the main purpose of determining whether the immunologically castrated boars have entered puberty. Boars are likely to be subject to meat tainting subsequent to the onset of puberty due to biological secretions which occur at that time. This method allows the majority of tainted meat to be screened out prior to delivery.

Growing community of inventors

Saskatoon, Canada

Roger A Pierson