Duphar International Research Bv

Solvay Pharmaceuticals, Gmbh

Solvay Pharmaceuticals, B.v.

Roelof Van Hes

Cornelis G Kruse

Arnoldus C Grosscurt

Bernard J Van Vliet

Martinus T M Tulp

Gerben M Visser

Jacobus Tipker

Johannes A M Van Der Heijden

Ineke Van Wijngaarden

Marius S Brouwer

Jan Hartog

Maurits E Vandewalle

Martinus Th M Tulp

Johannes A Van Der Heyden

Antonius Hulkenberg

Berend Olivier

Pieter Smid

Wouter Balk

Johan T Van Der Eycken

Christophorus M Keet

The invention relates to a novel group of phenylpiperazines having interesting pharmacological properties such as a high affinity for the dopamine Dreceptor and/or the serotonin reuptake site, and the ability to treat conditions related to disturbances in the dopaminergic and/or the serotonergic systems such as anxiety disorders, depression, Parkinson's disease, and schizophrenia. The invention relates to a group of novel phenylpiperazine derivatives of the formula (I): wherein:

Phenylpiperazine

Phenylpiperazines

The present invention relates to a group of novel tetrahydropyridin-4-yl indoles with a dual mode of action: serotonin reuptake inhibition and affinity for dopamine-Dreceptors, to methods for the preparation of these compounds and to novel intermediates useful for the synthesis of said tetrahydropyridin-4-yl indoles. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. The invention relates to novel tetrahydropyridin-4-yl indoles of the formula. and tautomers, stereoisomers, prodrugs, N-oxides, pharmacologically acceptable salts, hydrates and solvates thereof,wherein:

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The invention relates to a novel group of phenylpiperazines having interesting pharmacological properties such as a high affinity for the dopamine Dreceptor and/or the serotonin reuptake site, and the ability to treat conditions related to disturbances in the dopaminergic and/or the serotonergic systems such as aggression, anxiety disorders, autism, vertigo, depression, disturbances of cognition, disturbances of memory, Parkinson's disease, schizophrenia, and psychotic disorders. The invention relates to a group of novel phenylpiperazine derivatives of the formula (I): wherein:

3-Tetrahydropyridin-4-yl indoles for treatment of psychotic disorders

The invention relates to 3,4-dehydropiperidine derivatives having psychotropic activity, which compounds are represented by the general formula 1 ##STR1## wherein R is hydrogen or C.sub.1 -C.sub.3 alkyl;

3,4-dehydropiperidine derivatives having psychotropic activity

The invention relates to new di- and tetrahydroisoquinoline derivatives having interesting cytostatic properties, to the preparation of the said new compounds, and to compositions comprising such a compound as a cytostatically active substance.

Di- and tetrahydroisoquinoline derivatives

The invention relates to a group of new phenyl, pyrrolidin-2-yl substituted 5-ring heterocyclic compounds of the formula ##STR1## wherein A is an unsaturated heterocyclic 5-ring having at least one nitrogen or oxygen atom in the ring, with the proviso that the phenyl substituent is in a meta-position with respect to the 2-pyrrolidinyl substituent. The compounds have interesting pharmacological, notably antipsychotic properties.

Phenyl, Pyrrolidin-2-yl substituted pyrroles having antipsychotic

The invention relates to new benzoylurea compounds having insecticidal and acaricidal activity, of the general formula ##STR1## wherein R.sub.1 is a hydrogen atom or represents 1 or 2 halogen atoms;

Benzoylurea compounds, and insecticidal and acaricidal compositions

The invention relates to new benzoylurea compounds of the general formula ##STR1## wherein R.sub.1 is a hydrogen atom or represents 1 or 2 substituents which are selected from the group consisting of halogen and alkyl and haloalkyl having 1-4 carbon atoms,

The invention relates to new pyrazoline derivatives and to insecticidal compositions on the basis of the compounds. The compositions can be used for controlling insects in a dosage from 0.01 to 1 kg of active substance per hectare.

Insecticidal

The invention relates to new pyrazoline derivatives having insecticidal activity; the new compounds can be represented by the general formula ##STR1## wherein R is an alkoxycarbonyl group having 2 to 6 carbon atoms,

1-Alkoxycarbonylphenylcarbamoyl-3-phenyl-4-cyanoalkyl-2-pyrazolines and

The invention relates to new sulphonyl compounds of the general formula ##STR1## wherein X is a halogen atom, a phenoxy group, or an alkyl group or alkoxy group having 1-4 carbon atoms and substituted, if desired, with halogen;

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Weesp, Netherlands

Roelof Van Hes