Medivir Ab

Roelf Datema

Karl N Johansson

Bjorn G Lindborg

Bo F Oberg

Goran B Stening

Zsuzanna M Kovacs

Bo F Berg

Zsuzsanna M Kovacs

Kristina B Gotthammar

Bj Orn Lindborg

Antivirally active compounds of formula (I), wherein R.sup.1 is hydrogen, hydroxy, mercapto or amino; R.sup.2 is hydrogen, hydroxy, fluoro, chloro or amino; R.sup.3 and R.sup.4 are independently selected from (II), (III), amino, hydroxy or an ether or ester residue thereof, or R.sup.3 together with R.sup.4 is (IV), wherein M is hydrogen or a pharmaceutically acceptable counterion; and n is 1 or 2; with the proviso that, when R.sup.2 is amino and R.sup.3 and R.sup.4 are hydroxy, R.sup.1 is not hydroxy and in addition, when n=1, R.sup.1 is not hydrogen, and pharmaceutically acceptable salts thereof; processes for preparation of said compounds, a pharmaceutical composition comprising said compounds, methods for treatments of virus infections as well as use of compounds of formula (I) without the proviso for the manufacture of a medicament for treatment of AIDS. ##STR1##

Derivatives of purine, process for their preparation and a

The present invention is directed to a method of treating an HIV infection in a host in need of such treatment which comprises administering an effective anti-HIV amount of a compound having the formula ##STR1## wherein: R.sup.1 is hydrogen, hydroxyl;

A compound of the formula ##STR1## wherein the radicals A, X, R.sup.1, R.sup.2 and R.sup.3 are defined as follows:

.alpha. nucleoside compounds and a method for treating HBV using said

Use of a compound of the formula ##STR1## wherein A is .beta.-2'-deoxy-D-ribofuranosyl or .beta.-D-arabinofuranosyl;

Antiviral pharmaceutical composition comprising 5-substituted pyrimidine

A compound of the formula ##STR1## wherein the radicals A, X, R.sup.1, R.sup.2 and R.sup.3 are defined as follows: ##STR2## R.sup.2 : H; or R.sup.2 constitutes together with R.sup.3 with a carbon - carbon bond

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Cheshire, CT, United States of America

Roelf Datema