Massachusetts Institute of Technology

Stichting Nederlands Instituut Voor Zuivelonderzoek (nizo)

Roelant J Siezen

George B Benedek

John I Clark

Simon H Friedman

Oscar Paul Kuipers

Willem Meindert De Vos

John A Thomson

Christophe M Coppin

Geroge B Benedek

The invention relates primarily to a number of lantibiotics similar to nisin A, which differ from nisin A by substitution, deletion or insertion of one or more amino acids, such as, in particular, the naturally occurring analogue of nisin A, termed nisin Z, which has the structure given above. Lantibiotics of this type are particularly suitable for preserving foodstuffs for humans and animals. This preservation takes place by the use of these lantibiotics themselves or of microorganisms producing these lantibiotics, in particular lactic acid bacteria, in the preparation or storage of foodstuffs.

Lactic acid bacteria producing lantibiotics similar to nisin A

Lantibiotics similar to nisin a

The present invention relates to methods and pharmaceutical reagents for decreasing the phase separation temperature and inhibiting the formation of high molecular weight aggregates in eye lenses, thereby inhibiting or reversing cataract formation.

Chemical prevention or reversal of cataract by phase separation

Cataract in mammalian lenses can be prevented or reversed by applying a solution of an imidoester, a N-hydroxysuccinimide-ester or hydrogen peroxide to the lens under conditions that permit the solution to interact with the lens constituents.

Process for preventing or reversing cataract formation using protein

Growing community of inventors

Ede, Netherlands

Roelant J Siezen