Technion Research & Development Foundation Limited

Roee Amit

Orna Atar

Maayan Lufton

Alexey Tomsov

Yehonatan Zur

Leon Anavy

Lidya Tannenzapf

Roni Cohen

Shira Levi

Sagi Sheinkman

Dor Ben Meir

Zeinat Awwad

Tzila Davidov

Lior Levy

Yael Annis

Inbal Vaknin

Liron Abrahami Pachuk

Assaf Licht

Tal Ofek

Mai Dror

Lior Haim

Nitzan Shmuel

Nir Litver

Alexandra Ereskovsky

Ruth Veksler

Noa Eden

Ilan Brajzblat

Zohar Yakhini

Ofri Warsha

Liron Abrahami

Noa Katz

Adi Yannai

Hanriet Tibi

A data storage system and method are provided, as well as systems and methods for fabrication, and writing and reading of data therein. The data storage system includes at least one population of molecular sequences including chains of basic molecular building-blocks, and defining at least one respective data-block encoding data in the data storage system. The data of the data-block is encoded in a sequence S=(π, π, . . . , π. . . , π, π) of encoded letters {π} associated with an alphabet Σ≡{σ}|, which are encoded according to the types of basic molecular building-blocks appearing at k respective location along storage segments of the molecular sequences of the population. The molecular sequences include a number Z of different types of basic molecular building-blocks {E}|, while the alphabet Σ has a size M strictly greater than the number Z of types of building-blocks. Each alphabet letter σis associated with a vector {P}|indicative of occurrences of basic molecular building-block Eof type n in the alphabet letter σ. Accordingly each encoded letter πat location k in the storage segments of molecular sequences of the data-block/population, is mapped to a corresponding alphabet letter σby determining a match between the occurrence of basic molecular building-blocks of different types at that locations k of the molecular sequences of the population, with the vector {P}|associated with the alphabet letter σ. In some implementations the component Pof the vector {P}associated with alphabet letter σis indicative of a probability that a basic molecular building-block Eof type n,≤n≤Z, appears at the location k of the storage segment of a molecular strand of the at least one population in case the letter πencoded at that location k corresponds to the alphabet letter σ.

Molecular data storage systems and methods

Systems comprising a first polynucleotide comprising a regulatory element operatively linked to an open reading frame encoding an invertase enzyme and a second polynucleotide comprising a repressible regulatory element operatively linked to an open reading frame encoding a glucose oxidase enzyme wherein the repressible element inhibits transcription in response to hydrogen peroxide are provided. Cells and compositions comprising a system of the invention, as well as methods using the system of the invention, are also provided, as is artificial honey.

Bee-less honey

Chimeric polypeptides comprising a dihydrotestosterone (DHT) reductase moiety, such as 3 alpha-hydroxysteroid dehydrogenase (3&#x3b1;-HSD), fused to a signal peptide moiety, polynucleotides encoding same, and compositions comprising at least one microorganism cell capable of secreting the chimeric polypeptide, are provided. Further provided are methods and kits for treating, preventing or ameliorating androgen-dependent disorders, including but not limited to androgenic alopecia.

Composition and method for treating androgen-dependent disorders

Growing community of inventors

Haifa, Israel

Roee Amit