Spago Nanomedical Ab

Spago Imaging Ab

Rodrigo Petoral, Jr

Oskar Axelsson

Fredrik Ek

Petter Lauritzson

Sania Bäckström

Disclosed herein are globular nanostructures having a hydrodynamic diameter (D) of 8-100 nm comprising a central part and a peripheral part, wherein said central part has a calculated diameter (D) of 6-90 nm and said peripheral part has an estimated thickness (T) so that D=D+2T, wherein said central part comprises: (i) a crosslinked polymeric framework comprising monomer residues wherein at least 30% by number of the monomer residues have crosslinked thereby forming the crosslinked polymeric framework and/or (ii) a branched polymeric framework comprising monomer residues wherein the number of branch points is at least 30% of the number of monomer residues, wherein said central part comprises chelating groups of which at least 4 allow chelation of at least one multiply charged cation, wherein said chelating groups are independently selected from the group consisting of &#x2014;COOR, &#x2014;P&#x2550;O(OR)(OR), and &#x2014;S(&#x2550;O)OR, wherein Rand Rare independently selected from the group consisting of a negative charge, H, and lower alkyls, and wherein said peripheral part comprises a synthetic polymer material covalently attached to the central part, wherein the synthetic polymer material is hydrophilic and bioinert, and electrically neutral or zwitterionic. Also disclosed are compositions comprising such nanoparticles, and optionally also a radionuclide, use of such compositions, kits containing such compositions and methods for obtaining such compositions.

Nanostructures and applications thereof

Disclosed herein are nanostructures comprising a polymeric framework comprising at least five geminal bisphosphonate groups, wherein the geminal bisphosphonate groups independently of each other are incorporated as &#x2014;RRC(P&#x2550;O(OR)(OR)), wherein Rand Rare independently selected from the group consisting of a negative charge, H, alkyl and aryl, and wherein at least one of Rand Ris a group connected to the polymeric framework with the proviso that when only one of Rand Ris such a connected group, the other of Rand Ris either a group being able to connect to the polymeric framework, or the residue of such a group, or selected from the group consisting of H, OH, ORand R, wherein Ris a lower alkyl. The polymeric framework may comprise manganese ions. Disclosed are also methods for producing such manganese containing nanostructures, compositions comprising such manganese containing nanostructures and use of such manganese containing nanostructures, i.a. as MRI contrasting agents.

Growing community of inventors

Lund, Sweden

Rodrigo Petoral, Jr