Rhone-poulenc Rorer S.a.

Rhone-poulenc Sante

Rodolphe Margraff

Alain Gerbaud

Bernadette Mandard

Jean-Claude Gaullier

Andre Durand

Claude James

Jean-Claude Aloup

Andr&eacute; Durand

Gerard Jung

Arie Kies

Francois Floc'h

Thierry Kiener

Maurice Deschamps

4-acetoxy-2&agr;-benzoyloxy-5&bgr;, 20-epoxy-1&bgr;, 7&bgr;, 10&bgr;-trihydroxy-9-oxo-11-taxen-13&agr;-y1(2R,3S)-3-t-butoxycarbonylamino-3-phenyl-2-hydroxypropionate trihydrate obtained by a process of centrifugal partition chromatography.

4-Acetoxy-2&agr;-benzoyloxy-5&bgr;,20-epoxy-1&bgr;,7&bgr;,10&bgr;-trihydroxy-9-oxo-11-taxen-13&agr;-yl(2R,3S)-3-t-butoxycarbonylamino-3-phenyl-2-hydroxypropionate trihydrate

A method for purifying taxoids (Taxotere, 10-deacetylbaccatin III) by centrifugal partition chromatography.

Process for the purification of taxoids

Process for obtaining 10-deacetylbaccatin III from various parts of the yew (Taxus sp.) by extracting, with a suitable organic solvent, the aqueous solution obtained after treatment with water of the appropriate part of the yew or by adsorption of the aqueous solution on an appropriate substrate and desorption of 10-deacetylbaccatin III with a suitable solvent and then selective crystallization of 10-deacetylbaccatin III.

Process for obtaining 10-deacetylbaccatin III

Process for producing 10-deacetylbaccatin III from the various parts of the yew (Taxus sp.) by extraction and selective crystallization from a methanolic extract of the plant mass.

This invention relates to a process for obtaining 10-deacetylbaccatin III from various parts of yew (Taxus sp.) by extraction and selective crystallization starting with a methanolic extract of the vegetable matter.

This invention relates to a process for obtaining 10-deacetylbaccatin III from various parts of yew (Taxus sp.) by extraction with a suitable organic solvent of the aqueous solution obtained after treating the appropriate part of yew with water, followed by selective crystallization of 10-deacetylbaccatin III.

A compound of the elfamycin family, a process for preparing it and its use in the feeding of monogastric animals.

Elfamycin

Process for preparing (1R,2R)-2-(3-pyridyl)tetrahydrothiopyran-2-carbothioamide 1-oxides of general formula: ##STR1## (R.sub.1 =alkyl containing 1 to 4 carbon atoms), by the action of an alkyl isothiocyanate on the 1R,2R and 1R,2S sulphoxides of formulae: ##STR2## employed alone or mixed, the (1R,2R)-2-(3-pyridyl)tetrahydrothiopyran-2-carbothioamide 1-oxides thereby obtained and pharmaceutical compositions containing them. (1R,2R)-2-(3-Pyridyl)tetrahydrothiopyran-2-carbothioamide 1-oxides are especially useful as antihypertensives.

Process for preparing

The invention provides two novel immunosuppressant cyclodepsipeptides of formula: ##STR1## in which X is chlorine or hydrogen. These compounds may be made by culturing Streptomyces sp. S-16328 (CBS 162.86). The compound in which X is chlorine may be hydrogenolysed to give the compound in which X is hydrogen.

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Viry Chatillon, France

Rodolphe Margraff