Spa Societa Prodotti Antibiotici S.p.a.

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Societa Prodotti Antibiotici S.p.a.

Spa-societe Prodotti Antibiotici S.p.a.

Rodolfo Ferrari

Tiberio Bruzzese

Ernani Dell'Acqua

Giuseppe Ghielmetti

Sergio Magnaghi

Eustorgio Felci

The present invention provides a process for the preparation of alkyl esters of polyene antibiotics, wherein a polyene antibiotic is reacted with a diazoalkane in the presence of a basic substance. The present invention also provides, as new materials, alkyl esters of polyene antibiotics in which the alkyl radical of the ester grouping contains 2 or more carbon atoms.

Alkyl esters of polyene antibiotics

The present invention provides a water-soluble pharmaceutical complex, comprising the antibiotic partricin and/or an alkyl ester thereof and sodium desoxycholate and/or sodium dehydrocholate.

Water-soluble pharmaceutical complexes of partricin or an alkyl ester

The present invention is concerned with a new and improved process for the recovery of the polyene antibiotic partricin, wherein a surface-active agent is added to a fermented liquor containing partricin in an amount sufficient to bring the partricin into solution, whereafter insoluble material is removed and the partricin is recovered from the aqueous solution.

Process for the recovery and purification of partricin

There is provided a new process for the preparation of esters of 4,4'-dihydroxydiphenyl-(2-pyridyl)-methane of the general formula: ##SPC1## which Wherein R.sub.1 is a hydrogen atom or a sulpho group or an acyl radical and R.sub.2 is a hydrogen atom or a carboalkoxy radical, and the salts thereof with pharmaceutically-acceptable, non-toxic inorganic and organic bases. Those compounds in wich R.sub.2 is a carboalkoxy radical are new.

Process for preparing dihydroxydiphenylmethane derivatives

The present invention provides a water-soluble pharmaceutical composition, comprising partricin and/or partricin methyl ester in admixture with at least one anionic and/or cationic surfactant.

Water-solubilized antibiotics

The present invention provides new salts and complexes of lysozyme and of basic derivatives of lysozyme with bile acids, processes for the preparation thereof and the pharmaceutical use thereof.

Lysozyme derivatives

There are described preparations containing glucides and non-toxic, physiologically compatible salts of phosphorylated glucides which can be administered orally or parenterally.

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Milan, Italy

Rodolfo Ferrari