Abbott Laboratories Corporation

Rodney M Mittag

William L Rudzena

Edward S Tripp

Peter L Bryant

John K Moore

John E Hengeveld

Philip E Bauer

Nicolaos A Drivas

Richard R Copp, Jr

David B Murphey

Kimberly Ann Allen

Brian T Fohey

Brian S Moon

Greg S Lannoye

Dennis M Abad

Elise H Leese

John C Williams

The present invention provides a simple, 1-step process for preparing a N-(aryl or heteroaryl)-hydroxyurea comprising reacting the corresponding alcohol, ester or ether with hydroxyurea and acid. This reaction is particularly useful for preparing a benzo[b]thienyl substituted N-hydroxyurea of formula: ##STR1## from compound 1: ##STR2## by reacting compound 1 with hydroxyurea and acid. R.sup.1 is selected from the group consisting of hydrogen, 1-6 carbon alkyl, 1-6 carbon alkoxy, and halogen; R.sup.2 is an 1-4 carbon alkyl; and R.sup.3 is selected from the group consisting of hydrogen, acyl, methyl, ethyl and mixtures thereof. Additional steps to isolate the pure bulk product follow.

Synthesis and isolation of N-(aryl or heteroaryl)-alkyl-N-hydroxyurea

An ambulatory infusion and/or KVO (keep vein open) system (12, 18) has a gas-pressurized bladder arrangement (12) including a gas barrier associated therewith. The system includes a flexible bag of solution (13) inserted in a sleeve portion (36) of the bladder arrangement (12). Internal gas pressure which is developed within the bladder arrangement by a selectively initiated chemical reaction exerts a continuing pressure against the solution bag (13) to cause the solution to flow therefrom. A tubing set (18) of the system includes a flow restrictor (24) which is sized for minimal flow rates for indwelling catheter patency maintenance.

Ambulatory energized container system

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Chicago, IL, United States of America

Rodney M Mittag