Pfizer Corporation

Osi Pharmaceuticals, Inc.

Rodney C Schnur

Anton F Fliri

Reinhard Sarges

Allen R Kraska

Lee Daniel Arnold

James P Rizzi

Randall James Gallaschun

John L Belletire

Mikel Paul Moyer

The invention relates to compounds of the formulaand to pharmaceutically acceptable salts thereof, wherein R, R, R, R, n and m are as defined herein. The compounds of formula I are useful in the treatment of hyperproliferative diseases, such as cancer. The invention further relates to processes of making the compounds of formula I and to methods of using such compounds in the treatment of hyperproliferative diseases.

Alkynl and azido-substituted 4-anilinoquinazolines

Phenylamino-substituted tricyclic derivatives for treatment of hyperproliferative diseases

Ansamycin derivatives as antioncogene and anticancer agents

The invention relates to compounds of the formula ##STR1## and to pharmaceutically acceptable salts thereof, wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, n and m are as defined herein. The compounds of formula I are useful in the treatment of hyperproliferative diseases, such as cancer. The invention further relates to processes of making the compounds of formula I and to methods of using such compounds in the treatment of hyperproliferative diseases.

Alkynyl and azido-substituted 4-anilinoquinazolines

This invention relates to compounds of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and X are as defined below. Such compounds are useful as oncogene inhibitors and antitumor agents.

Bicyclic ansamycins

Acyl derivatives of 2-aminobenzothiazole and alkylated analogs thereof as antitumor agents.

Aromatic and heterocyclic carboxamide derivatives as antineoplastic

Compounds of the formula ##STR1## where Het is a heterocyclic group, n is an integer of 0 to 2 and R.sup.1 is hydrogen or lower alkyl are protease inhibitors useful as anti-plasmin and anti-thrombin agents.

Benzamide protease inhibitors

Compounds of the formula ##STR1## where HET is a heterocyclic group, n is an integer of 0 to 2 and R.sup.1 is hydrogen or lower alkyl are protease inhibitors useful as anti-plasmin and antithrombin agents.

Compounds of the formula ##STR1## where HET is a heterocyclic group, n is an integer of 0 to 2 and R.sup.1 is hydrogen or lower alkyl are protease inhibitors use as anti-plasmin and anti-thrombin agents.

Hypoglycemic 5-chromanyl, 2,3-dihydro-5-benzo[b]-furanyl, 5-pyridyl, 5-quinolyl, 5-pyrrolyl, 5-indolyl, 5-thiazolyl, 5-oxazolyl, 5-isothiazolyl and 5-isoxazolyl oxazolidine-2,4-diones and the pharmaceutically-acceptable salts thereof; certain 3-acylated derivatives thereof; a method of treating hyperglycemic animals therewith; and intermediates useful in the preparation of said compounds.

Hypoglycemic 5-substituted oxazolidine-2,4-diones

Hypoglycemic 5-furyl and 5-thienyl derivatives of oxazolidine-2,4-dione and the pharmaceutically-acceptable salts thereof; certain 3-acylated derivatives thereof; and intermediates useful in the preparation of said compounds.

Hypoglycemic 5-substituted oxazolidine 2,4-diones

Tetracyclic spiro-hydantoin aldose reductase inhibitors and compositions

A series of 5-(2-alkoxyphenyl)thiazolidinediones and pharmaceutically acceptable salts thereof useful as hypoglycemic agents, aldose reductase inhibitors and as therapeutic agents for the treatment of chronic diabetic complications; intermediates therefore; and process for preparation of said compounds.

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Noank, CT, United States of America

Rodney C Schnur