The Brigham and Women's Hospital, Inc.

Wesleyan University

Roderick V Jensen

Steven R Gullans

Raphael Bueno

Gavin J Gordon

Li-Li Hsiao

Clemens R Scherzer

The invention provides methods for diagnosing biological states or conditions based on ratios of gene expression data from tissue samples, such as cancer tissue samples. The invention also provides sets of genes that are expressed differentially in malignant pleural mesothelioma. These sets of genes can be used to discriminate between normal and malignant tissues, and between classes of malignant tissues. Accordingly, diagnostic assays for classification of tumors, prediction of tumor outcome, selecting and monitoring treatment regimens and monitoring tumor progression/regression also are provided.

Diagnostic and prognostic tests

The present invention identifies a number of gene markers whose expression is altered in neurodegenerative diseases (ND). These markers can be used to diagnose or predict ND in subjects, and can be used in the monitoring of therapies. In addition, these genes identify therapeutic targets, the modification of which may prevent ND development or progression.

Prediction of Parkinson's disease using gene expression levels of peripheral blood samples

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Pelham, MA, United States of America

Roderick V Jensen