Sanofi

Heidelberg Pharma Research Gmbh

Pentracor Gmbh

Technische Unversität Berlin

Roderich Süssmuth

Joachim Wink

Gerhard Seibert

Irvin Winkler

Hans Guehring

Luigi Toti

John Weston

Mark Broenstrup

Ahmed Sheriff

Julian Kretz

Gerhard Jas

Stephan Mattecka

Dennis Kerwat

Iraj Behroz

Holger Hoffmann

Vera Meyer

Monique Royer

Patrick Michael Durkin

Christoph Wink

Dirk Storm

Victor Prisyazhnoy

Lennart Richter

Marius Morkunas

Sophia Zobel

Franziska Wanka

László Vértesy

George M Sheldrick

Kathrin Meindl

Vivien Schubert

Caroline Knittel

Lieby Zborovsky

Simon Boecker

Alexander Pesic

Mary-Ann Siegert

Stefan GRÄTZ

Leonard Von Eckardstein

Stéphane Cociancich

Philippe Rott

Manuela HÜGELLAND

Agnes MÜHLENWEG

George Sheldrick

The invention relates to a method for the preparation of a 4,5-dihydroxyisoleucine derivative comprising the steps of asymmetric Claisen rearrangement of a Z-aminocrotyl-glycin ester and subsequent kinetic resolution of the product diastereomer mix by acylase, and subsequent Sharpless dihydroxylation of the resulting 2-amino-3-methylpent-4-enoic acid derivative.

Synthesis of (2S,3R,4R)-4,5-dihydroxyisoleucine and derivatives

The present invention provides phosphoryl choline derivatives of general formula (I), which are suitable to be immobilized on a solid support to provide a separation material of general formula (II), which bind with both high affinity and high specificity to a protein, more specifically to C-reactive protein and anti-phosphoryl choline antibodies. Said separation materials are particularly useful in the extracorporeal removal of C-reactive protein and anti-phosphoryl choline antibodies from a biological fluid of a patient for prophylaxis and/or treatment of immune dysfunctions and cardiovascular diseases. Also provided is a column that comprises the separation material of general formula (II), as well as a device containing the column. Formula (I), wherein variable X is selected from: &#x2014;SH, &#x2014;NHR, &#x2014;C&#x2550;CH, &#x2014;CH&#x2550;CH, &#x2014;Nand &#x2014;CHO; the other variables are as defined in the claims: Formula (II), wherein variable 'A' represents a solid support. 'A' as well as the other variables are defined in detail in the claims. 

Separation material comprising phosphoryl choline derivatives

The disclosure relates to a compound of the formula (I) wherein

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Berlin, Germany

Roderich Süssmuth