Lakewood Amedex, Inc.

Other

Oligos Etc. Inc.

Roderic Mk Dale

Amy Arrow

Tod M Woolf

Terry Thompson

Steven L Gatton

Lun-Quan Sun

Teresa Thompson

The invention provides compositions of oligonucleotides targeted at influenza genes and at host animal genes involved in response to influenza infection. In some embodiments, the oligonucleotides are modified. In some embodiments, the compositions contain one, or more than one, oligonucleotide. The invention also provides methods and kits using the compositions of the invention for the treatment and prevention of influenza.

Compositions and methods for the treatment of influenza infection

The present invention relates to methods and compositions containing oligonucleotides suitable for administration to humans and other mammals.

Oligonucleotide&#x2014;containing pharmacological compositions and their use

This invention relates to antisense oligonucleotides that target mRNAs in cells as substrates for the cellular enzyme RNase H and thereby cause specific degradation of the targeted mRNA. The oligonucleotides have three components: a RNase H activating region, a complementarity region and 3' and 5' ends. The invention optimizes each of the components to resist intracellular nucleases, to increase hybridization to target mRNA, to specifically inactivate target mRNA in cells, and to decrease cytotoxicity.

Three component chimeric antisense oligonucleotides

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Wilsonville, OR, United States of America

Roderic Mk Dale