Leland Stanford Junior University

Roch Houot

Ronald Levy

Arash Ash Alizadeh

Holbrook Kohrt

Matthew J Goldstein

James Torchia

Methods are provided to enhance the efficacy of antibody therapy directed to tumor cells.

Methods for enhancing anti-tumor antibody therapy

Methods of enhancing the efficacy of antibody-directed cellular cytotoxicity (ADCC) for therapy directed to killing of tumor cells are disclosed. Cancer specific cell surface antigens are bound by monoclonal antibodies, thereby stimulating a cytotoxic T cell response characterized by an upregulation of cell surface expression of costimulatory molecules on the T cell. The ADCC response is augmented by the subsequent administration of a second antibody that is an agonist of the costimulatory molecule.

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Rennes, France

Roch Houot